Special Section on Selected Topics in Biophotonics: Optical Coherence Tomography and Medical Imaging Using Diffuse Optics

Tissue surface as the reference arm in Fourier domain optical coherence tomography

[+] Author Affiliations
Nikola Krstajić

University of Edinburgh, School of Engineering, Institute for Integrated Micro and Nano Systems, Faraday Building, Kings Buildings, Mayfield Road, Edinburgh EH93JL, United Kingdom

Christian Tom A. Brown, Kishan Dholakia

University of St. Andrews, SUPA School of Physics and Astronomy, North Haugh, St. Andrews KY16 9SS, United Kingdom

Mario Ettore Giardini

University of St. Andrews, School of Medicine, North Haugh, St. Andrews KY16 9TF, United Kingdom

J. Biomed. Opt. 17(7), 071305 (May 15, 2012). doi:10.1117/1.JBO.17.7.071305
History: Received October 2, 2011; Revised February 16, 2012; Accepted February 22, 2012
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Abstract.  We present a simple method applicable to common-path Fourier domain optical coherence tomography (OCT) in which the tissue surface is used as the reference arm. We propose using aluminium hydroxide powder as a potential tissue surface diffuser to allow wider application of this method. This technique allows one to avoid placing a reference arm reflective element, such as glass plate, on tissue, and intrinsically avoids both coherent and complex conjugate mirror artifacts associated with glass plates. Aluminium hydroxide can be sprayed onto tissue using spray nozzles commonly found in endoscopes. The sensitivity of the tissue reference arm common-path OCT image is 94 dB for a 50-µs charge-coupled device integration time, and 97.5 dB for a 200-µs CCD integration time.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Nikola Krstajić ; Christian Tom A. Brown ; Kishan Dholakia and Mario Ettore Giardini
"Tissue surface as the reference arm in Fourier domain optical coherence tomography", J. Biomed. Opt. 17(7), 071305 (May 15, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.7.071305


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