Research Papers: Imaging

Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography

[+] Author Affiliations
Muhammad Rameez Chatni, Jun Xia, Konstantin Maslov, Zijian Guo, Kun Wang, Mark Anastasio, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, St. Louis, Missouri 63130

Rebecca Sohn, Jeffrey Arbeit

Washington University in St. Louis, Urology Division, Department of Surgery, St. Louis, Missouri 63110

Yu Zhang, Younan Xia

Georgia Institute of Technology and Emory University, Wallace H. Coulter Department of Biomedical Engineering, Atlanta, Georgia 30332

J. Biomed. Opt. 17(7), 076012 (Jul 06, 2012). doi:10.1117/1.JBO.17.7.076012
History: Received March 15, 2012; Revised June 4, 2012; Accepted June 6, 2012
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Abstract.  With the increasing use of small animals for human disease studies, small-animal whole-body molecular imaging plays an important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose molecular information, leading to higher costs of building dual-modality systems. Even with image co-registration, the spatial resolution of the molecular imaging modality is not improved. Utilizing a ring-shaped confocal photoacoustic computed tomography system, we demonstrate, for the first time, that both anatomy and glucose uptake can be imaged in a single modality. Anatomy was imaged with the endogenous hemoglobin contrast, and glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose.

Figures in this Article
© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Muhammad Rameez Chatni ; Jun Xia ; Rebecca Sohn ; Konstantin Maslov ; Zijian Guo, et al.
"Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography", J. Biomed. Opt. 17(7), 076012 (Jul 06, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.7.076012


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