Research Papers: Imaging

Out-of-plane Stokes imaging polarimeter for early skin cancer diagnosis

[+] Author Affiliations
Pejhman Ghassemi

Catholic University of America, Washington, District of Columbia 20064

Washington Hospital Center, MedStar Health Research Institute, Washington, District of Columbia 20010

Paul Lemaillet, Jessica C. Ramella-Roman

Catholic University of America, Washington, District of Columbia 20064

Thomas A. Germer

National Institute of Standards and Technology, Gaithersburg, Maryland 20899

Jeffrey W. Shupp, Suraj S. Venna, Marc E. Boisvert, Katherine E. Flanagan, Marion H. Jordan

Washington Hospital Center, MedStar Health Research Institute, Washington, District of Columbia 20010

J. Biomed. Opt. 17(7), 076014 (Jul 09, 2012). doi:10.1117/1.JBO.17.7.076014
History: Received December 20, 2011; Revised June 1, 2012; Accepted June 6, 2012
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Abstract.  Optimal treatment of skin cancer before it metastasizes critically depends on early diagnosis and treatment. Imaging spectroscopy and polarized remittance have been utilized in the past for diagnostic purposes, but valuable information can be also obtained from the analysis of skin roughness. For this purpose, we have developed an out-of-plane hemispherical Stokes imaging polarimeter designed to monitor potential skin neoplasia based on a roughness assessment of the epidermis. The system was utilized to study the rough surface scattering for wax samples and human skin. The scattering by rough skin—simulating phantoms showed behavior that is reasonably described by a facet scattering model. Clinical tests were conducted on patients grouped as follows: benign nevi, melanocytic nevus, melanoma, and normal skin. Images were captured and analyzed, and polarization properties are presented in terms of the principal angle of the polarization ellipse and the degree of polarization. In the former case, there is separation between different groups of patients for some incidence azimuth angles. In the latter, separation between different skin samples for various incidence azimuth angles is observed.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Pejhman Ghassemi ; Paul Lemaillet ; Thomas A. Germer ; Jeffrey W. Shupp ; Suraj S. Venna, et al.
"Out-of-plane Stokes imaging polarimeter for early skin cancer diagnosis", J. Biomed. Opt. 17(7), 076014 (Jul 09, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.7.076014


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