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Special Section on Optical Diagnostic and Biophotonic Methods from Bench to Bedside

High-density diffuse optical tomography of term infant visual cortex in the nursery

[+] Author Affiliations
Steve M. Liao, Terrie E. Inder

Washington University School of Medicine, Department of Pediatrics, 660 S. Euclid Ave, St. Louis, Missouri 63110

Silvina L. Ferradal

Washington University, Department of Biomedical Engineering, Whitaker Hall, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130

Washington University School of Medicine, Department of Radiology, 660 S. Euclid Ave, St. Louis, Missouri 63110

Brian R. White

Washington University School of Medicine, Department of Radiology, 660 S. Euclid Ave, St. Louis, Missouri 63110

Washington University, Department of Physics, Campus Box 1105, One Brookings Drive, St. Louis, Missouri 63130

Nicholas Gregg

University of Pittsburgh School of Medicine, M240 Scaife Hall, 3550 Terrace Street, Pittsburgh, Pennsylvania 15261

Joseph P. Culver

Washington University, Department of Biomedical Engineering, Whitaker Hall, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130

Washington University School of Medicine, Department of Radiology, 660 S. Euclid Ave, St. Louis, Missouri 63110

Washington University, Department of Physics, Campus Box 1105, One Brookings Drive, St. Louis, Missouri 63130

J. Biomed. Opt. 17(8), 081414 (Jul 09, 2012). doi:10.1117/1.JBO.17.8.081414
History: Received December 28, 2011; Revised June 5, 2012; Accepted June 8, 2012
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Abstract.  Advancements in antenatal and neonatal medicine over the last few decades have led to significant improvement in the survival rates of sick newborn infants. However, this improvement in survival has not been matched by a reduction in neurodevelopmental morbidities with increasing recognition of the diverse cognitive and behavioral challenges that preterm infants face in childhood. Conventional neuroimaging modalities, such as cranial ultrasound and magnetic resonance imaging, provide an important definition of neuroanatomy with recognition of brain injury. However, they fail to define the functional integrity of the immature brain, particularly during this critical developmental period. Diffuse optical tomography methods have established success in imaging adult brain function; however, few studies exist to demonstrate their feasibility in the neonatal population. We demonstrate the feasibility of using recently developed high-density diffuse optical tomography (HD-DOT) to map functional activation of the visual cortex in healthy term-born infants. The functional images show high contrast-to-noise ratio obtained in seven neonates. These results illustrate the potential for HD-DOT and provide a foundation for investigations of brain function in more vulnerable newborns, such as preterm infants.

Figures in this Article
© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Steve M. Liao ; Silvina L. Ferradal ; Brian R. White ; Nicholas Gregg ; Terrie E. Inder, et al.
"High-density diffuse optical tomography of term infant visual cortex in the nursery", J. Biomed. Opt. 17(8), 081414 (Jul 09, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.8.081414


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