Special Section on Laser Technologies for Biomedical Applications

Quantitative estimation of mechanical and optical properties from ultrasound assisted optical tomography data

[+] Author Affiliations
Mayanglambam Suheshkumar Singh, Kanhirodan Rajan

Indian Institute of Science, Department of Physics, Bangalore 560012, India

Ram Mohan Vasu

Indian Institute of Science, Department of Instrumentation and Applied Physics, Bangalore 560012, India

Debasish Roy

Indian Institute of Science, Department of Civil Engineering, Bangalore 560012, India

J. Biomed. Opt. 17(10), 101507 (Jun 22, 2012). doi:10.1117/1.JBO.17.10.101507
History: Received November 22, 2011; Revised March 30, 2012; Accepted April 18, 2012
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Abstract.  We demonstrate quantitative optical property and elastic property imaging from ultrasound assisted optical tomography data. The measurements, which are modulation depth M and phase ϕ of the speckle pattern, are shown to be sensitively dependent on these properties of the object in the insonified focal region of the ultrasound (US) transducer. We demonstrate that Young’s modulus (E) can be recovered from the resonance observed in M versus ω (the US frequency) plots and optical absorption (μa) and scattering (μs) coefficients from the measured differential phase changes. All experimental observations are verified also using Monte Carlo simulations.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Mayanglambam Suheshkumar Singh ; Kanhirodan Rajan ; Ram Mohan Vasu and Debasish Roy
"Quantitative estimation of mechanical and optical properties from ultrasound assisted optical tomography data", J. Biomed. Opt. 17(10), 101507 (Jun 22, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.10.101507


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