Research Papers: Sensing

Reflectance model for acetowhite epithelium

[+] Author Affiliations
George Zonios

University of Ioannina, Department of Materials Science and Engineering, 45110 Ioannina, Greece

J. Biomed. Opt. 17(8), 087003 (Sep 04, 2012). doi:10.1117/1.JBO.17.8.087003
History: Received May 8, 2012; Revised June 26, 2012; Accepted July 10, 2012
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Abstract.  Application of low concentration acetic acid solution to various types of human epithelia, in vivo, is a well-established technique for the visual identification of neoplastic and potential precancerous lesions, especially in the cervix. An acetic acid application produces a transient whitening effect associated with the aforementioned lesions (acetowhite effect). In this article, a simple semi-empirical tissue reflectance model is presented, which describes the acetowhite effect in terms of the tissue’s optical properties and layered structure. The model successfully describes data available in the literature, explains basic characteristics of the acetowhite effect, and can serve as the basis for the development of more accurate and reliable noninvasive diagnostic methodologies for precancerous epithelial lesions.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

George Zonios
"Reflectance model for acetowhite epithelium", J. Biomed. Opt. 17(8), 087003 (Sep 04, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.8.087003


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