Research Papers: Therapeutic

Fluorescence spectra of blood and urine for cervical cancer detection

[+] Author Affiliations
Vadivel Masilamani, Mohamad Saleh AlSalhi

King Saud University, College Of Science, Department of Physics and Astronomy, P.O. Box 2455, Riyadh, Kingdom of Saudi Arabia

King Saud University, College of Science, Research Chair for Laser Diagnosis of Cancer, Physics and Astronomy Department, Riyadh, Saudi Arabia

Trinka Vijmasi

Thendrel Inc., 13114 Moss Ranch lane, Fairfax, Virginia

Kanaganaj Govindarajan

GVN Cancer Hospital, Trichy-2, India

Ram Rathan Rai

Rai Memorial Cancer Hospital, Chennai 600018, India

Muhammad Atif, Saradh Prasad

King Saud University, College of Science, Research Chair for Laser Diagnosis of Cancer, Physics and Astronomy Department, Riyadh, Saudi Arabia

Abdullah S. Aldwayyan

King Saud University, College Of Science, Department of Physics and Astronomy, P.O. Box 2455, Riyadh, Kingdom of Saudi Arabia

J. Biomed. Opt. 17(9), 098001 (Sep 06, 2012). doi:10.1117/1.JBO.17.9.098001
History: Received December 14, 2011; Revised July 24, 2012; Accepted August 7, 2012
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Abstract.  In the current study, the fluorescence emission spectra (FES) and Stokes shift spectra (SSS) of blood and urine samples of cervical cancer patients were obtained and compared to those of normal controls. Both spectra showed that the relative intensity of biomolecules such as porphyrin, collagen, Nicotinamide adenine dinucleotide, and flavin were quite out of proportion in cervical cancer patients. The biochemical mechanism for the elevation of these fluorophores is not yet definitive; nevertheless, these biomolecules could serve as tumor markers for diagnosis, screening, and follow-up of cervical cancers. To the best of our knowledge, this is the first report on FES and SSS of blood and urine of cervical cancer patients to give a sensitivity of 80% and specificity of 78%.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Vadivel Masilamani ; Mohamad Saleh AlSalhi ; Trinka Vijmasi ; Kanaganaj Govindarajan ; Ram Rathan Rai, et al.
"Fluorescence spectra of blood and urine for cervical cancer detection", J. Biomed. Opt. 17(9), 098001 (Sep 06, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.9.098001


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