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Research Papers: Imaging

Approximation error method can reduce artifacts due to scalp blood flow in optical brain activation imaging

[+] Author Affiliations
Juha Heiskala, Simon R. Arridge

University College London, Department of Computer Science, Gower Street, London WC1E 6BT, United Kingdom

Ville Kolehmainen

University of Eastern Finland, Department of Applied Physics, P.O. Box 1627, 70211 Kuopio, Finland

Tanja Tarvainen

University College London, Department of Computer Science, Gower Street, London WC1E 6BT, United Kingdom

University of Eastern Finland, Department of Applied Physics, P.O. Box 1627, 70211 Kuopio, Finland

Jari. P. Kaipio

University of Eastern Finland, Department of Applied Physics, P.O. Box 1627, 70211 Kuopio, Finland

University of Auckland, Department of Mathematics, Private Bag 92019, Auckland Mail Centre, Auckland 1142, New Zealand

J. Biomed. Opt. 17(9), 096012 (Sep 14, 2012). doi:10.1117/1.JBO.17.9.096012
History: Received March 30, 2012; Revised July 19, 2012; Accepted August 3, 2012
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Abstract.  Diffuse optical tomography can image the hemodynamic response to an activation in the human brain by measuring changes in optical absorption of near-infrared light. Since optodes placed on the scalp are used, the measurements are very sensitive to changes in optical attenuation in the scalp, making optical brain activation imaging susceptible to artifacts due to effects of systemic circulation and local circulation of the scalp. We propose to use the Bayesian approximation error approach to reduce these artifacts. The feasibility of the approach is evaluated using simulated brain activations. When a localized cortical activation occurs simultaneously with changes in the scalp blood flow, these changes can mask the cortical activity causing spurious artifacts. We show that the proposed approach is able to recover from these artifacts even when the nominal tissue properties are not well known.

Figures in this Article
© 2012 Society of Photo-Optical Instrumentation Engineers

Topics

Blood ; Brain ; Absorption ; Tissues

Citation

Juha Heiskala ; Ville Kolehmainen ; Tanja Tarvainen ; Jari. P. Kaipio and Simon R. Arridge
"Approximation error method can reduce artifacts due to scalp blood flow in optical brain activation imaging", J. Biomed. Opt. 17(9), 096012 (Sep 14, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.9.096012


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