Research Papers: Imaging

Intravascular photoacoustic imaging at 35 and 80 MHz

[+] Author Affiliations
Xiang Li, Qifa Zhou, K. Kirk Shung

University of Southern California, Department of Biomedical Engineering, NIH Ultrasonic Transducer Resource Center, Los Angeles, California 90089

Wei Wei

University of California, Irvine, Beckman Laser Institute, Irvine, California 92612

Wuhan University, Department of Physics and Key Laboratory of Acoustic and Photonic Materials and Devices, Wuhan 430072, China

Zhongping Chen

University of California, Irvine, Beckman Laser Institute, Irvine, California 92612

University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697

University of California, Irvine, Edwards Lifesciences Center for Advanced Cardiovascular Technology, Irvine, California 92697

J. Biomed. Opt. 17(10), 106005 (Oct 01, 2012). doi:10.1117/1.JBO.17.10.106005
History: Received February 5, 2012; Revised September 1, 2012; Accepted September 7, 2012
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Abstract.  The catheter-based intravascular photoacoustic (IVPA) imaging for diagnosing atherosclerosis, which can provide optical absorption contrast of the arterial wall besides acoustic scattering contrast from the conventional intravascular ultrasound (IVUS) imaging, has been intensively researched recently. The resolution of IVPA is determined by the frequency bandwidth of an ultrasonic transducer. Higher resolution can be achieved by increasing the transducer’s working frequency and bandwidth. We introduce IVPA imaging at 35 and 80 MHz by using newly designed integrated IVUS/IVPA probes. This is the first time IVPA has been achieved as high as 80 MHz. Six-micrometer tungsten wires were imaged to evaluate the probes’ spatial resolutions and beam patterns. Healthy rabbit aorta was imaged in vitro. Imaging results show that IVPA has superior contrast over IVUS in identifying the arterial wall, and IVPA at 80 MHz demonstrates extraordinary resolution (35 μm) compared to 35 MHz.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Xiang Li ; Wei Wei ; Qifa Zhou ; K. Kirk Shung and Zhongping Chen
"Intravascular photoacoustic imaging at 35 and 80 MHz", J. Biomed. Opt. 17(10), 106005 (Oct 01, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.10.106005


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