Research Papers: General

Ex vivo determination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography

[+] Author Affiliations
Qingliang Zhao, Chuanqing Zhou, Xinyu Chai

Shanghai Jiao Tong University, School of Biomedical Engineering, No. 800 Dongchuan Road, Shanghai 200240, China

Huajiang Wei

South China Normal University, MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, Guangzhou 510631, Guangdong Province, China

Yonghong He

Tsinghua University, Laboratory of Optical Imaging and Sensing, Graduate School at Shenzhen, Shenzhen 518055, China

Qiushi Ren

Peking University, College of Engineering, Department of Biomedical Engineering, Beijing 100871, China

J. Biomed. Opt. 17(10), 105004 (Oct 01, 2012). doi:10.1117/1.JBO.17.10.105004
History: Received March 31, 2012; Revised August 31, 2012; Accepted September 5, 2012
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Abstract.  Recent reports have suggested that spectral domain optical coherence tomography (SD-OCT) is a useful tool for quantifying the permeability of hyperosmotic agents in various tissues. We report our preliminary results on quantification of glucose diffusion and assessment of the optical attenuation change due to the diffusion of glucose in normal and adenomatous human colon tissues in vitro by using a SD-OCT and then calculated the permeability coefficients (PC) and optical attenuation coefficients (AC). The PC of a 30% aqueous solution of glucose was 3.37±0.23×106cm/s in normal tissue and 5.65±0.16×106cm/s in cancerous colon tissue. Optical AC in a normal colon ranged from 3.48±0.37 to 2.68±0.82mm1 and was significantly lower than those seen in the cancerous tissue (8.48±0.95 to 3.16±0.69mm1, p<0.05). The results suggest that quantitative measurements of using PC and AC from OCT images could be a potentially powerful method for colon cancer detection.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Qingliang Zhao ; Chuanqing Zhou ; Huajiang Wei ; Yonghong He ; Xinyu Chai, et al.
"Ex vivo determination of glucose permeability and optical attenuation coefficient in normal and adenomatous human colon tissues using spectral domain optical coherence tomography", J. Biomed. Opt. 17(10), 105004 (Oct 01, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.10.105004


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