Research Papers: Imaging

Intravascular photoacoustic imaging of exogenously labeled atherosclerotic plaque through luminal blood

[+] Author Affiliations
Doug Yeager, Andrei Karpiouk, Bo Wang

University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712

James Amirian, Richard Smalling

University of Texas Health Science Center, Division of Cardiology, Houston, Texas 77030

Konstantin Sokolov, Stanislav Emelianov

University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712

M.D. Anderson Cancer Center, Department of Imaging Physics, Houston, Texas 77030

J. Biomed. Opt. 17(10), 106016 (Oct 17, 2012). doi:10.1117/1.JBO.17.10.106016
History: Received May 15, 2012; Revised September 17, 2012; Accepted September 20, 2012
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Abstract.  Combined intravascular ultrasound and intravascular photoacoustic (IVUS/IVPA) imaging has been previously established as a viable means for assessing atherosclerotic plaque morphological and compositional characteristics using both endogenous and exogenous contrast. In this study, IVUS/IVPA imaging of atherosclerotic rabbit aortas following systemic injection of gold nanorods (AUNRs) with peak absorbance within the tissue optical window is performed. Ex vivo imaging results reveal a high photoacoustic signal from localized AUNRs in regions with atherosclerotic plaques. Corresponding histological staining further confirms the preferential extravasation of AUNRs in atherosclerotic regions with compromised luminal endothelium and acute inflammation. The ability to detect AUNRs using combined IVUS and photoacoustic imaging in the presence of luminal saline and luminal blood is evaluated using both spectroscopic and single wavelength IVPA imaging techniques. Results demonstrate that AUNR detection within the arterial wall can be achieved using both methods, even in the case of imaging through luminal blood.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Doug Yeager ; Andrei Karpiouk ; Bo Wang ; James Amirian ; Konstantin Sokolov, et al.
"Intravascular photoacoustic imaging of exogenously labeled atherosclerotic plaque through luminal blood", J. Biomed. Opt. 17(10), 106016 (Oct 17, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.10.106016


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