Research Papers: Imaging

Epithelium and Bowman’s layer thickness and light scatter in keratoconic cornea evaluated using ultrahigh resolution optical coherence tomography

[+] Author Affiliations
Rahul Yadav

University of Rochester, The Institute of Optics, 275 Hutchinson Road, Rochester, New York 14627

Ranjini Kottaiyan

University of Rochester, Flaum Eye Institute, 210 Crittenden Boulevard, Rochester, New York 14642

Kamran Ahmad

University of Rochester, Center for Visual Science, 274 Meliora Hall, Rochester, New York 14627

Geunyoung Yoon

University of Rochester, The Institute of Optics, 275 Hutchinson Road, Rochester, New York 14627

University of Rochester, Flaum Eye Institute, 210 Crittenden Boulevard, Rochester, New York 14642

University of Rochester, Center for Visual Science, 274 Meliora Hall, Rochester, New York 14627

J. Biomed. Opt. 17(11), 116010 (Nov 01, 2012). doi:10.1117/1.JBO.17.11.116010
History: Received July 31, 2012; Revised October 9, 2012; Accepted October 10, 2012
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Abstract.  A custom-developed ultrahigh resolution optical coherence tomography with an axial resolution of 1.1 μm in corneal tissue was used to characterize thickness and light scatter of the epithelium and Bowman’s layer in keratoconic (KC) cornea noninvasively. A 4-mm wide vertical corneal section around the apex in nine KC and eight normal eyes was imaged in vivo. The epithelium and Bowman’s layer were visualized and their thickness profiles were quantified. Scatter was quantified based on the sensitivity normalized mean signal intensity distribution. Average mean thickness of the epithelium and Bowman’s layer in KC eyes was significantly smaller (p<0.05) than the normal eyes. The epithelium thickness variation across a central 3-mm cornea was significantly larger in KC eyes than in normal eyes. The scatter in KC eyes was significantly increased only for Bowman’s layer. The changes observed in this study could improve our understanding of the underlying disease mechanism of KC and can provide new indications for early disease diagnosis.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Rahul Yadav ; Ranjini Kottaiyan ; Kamran Ahmad and Geunyoung Yoon
"Epithelium and Bowman’s layer thickness and light scatter in keratoconic cornea evaluated using ultrahigh resolution optical coherence tomography", J. Biomed. Opt. 17(11), 116010 (Nov 01, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.11.116010


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