Research Papers: Sensing

Detection of cerebral autoregulation by near-infrared spectroscopy in neonates: performance analysis of measurement methods

[+] Author Affiliations
Alexander Caicedo, Sabine Van Huffel

Department of Electrical Engineering ESAT, KU Leuven, SCD-SISTA, Leuven 3001, Belgium

iMinds Future Health Department, Leuven 3001, Belgium

Gunnar Naulaers

University Hospital Gasthuisberg, Neonatal Intensive Care Unit, KU Leuven, Leuven 3000, Belgium

Petra Lemmers, Martin Wolf

University Medical Centre, Department of Neonatology, Wilhelmina Children’s Hospital, Utrecht 3584 CX, The Netherlands

Frank van Bel

University Hospital Zurich, Biomedical Optics Research Laboratory, Clinic of Neonatology, Zurich 8091, Switzerland

J. Biomed. Opt. 17(11), 117003 (Nov 01, 2012). doi:10.1117/1.JBO.17.11.117003
History: Received June 6, 2012; Revised September 23, 2012; Accepted October 1, 2012
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Abstract.  Cerebral Autoregulation, in clinical practice, is assessed by means of correlation or coherence analysis between mean arterial blood pressure (MABP) and cerebral blood flow (CBF). However, even though there is evidence linking cerebral autoregulation assessment with clinical outcome in preterm infants, available methods lack precision for clinical use. Classical methods, used for cerebral autoregulation, are influenced by the choice of parameters such as the length of the epoch under analysis and the choice of suitable frequency bands. The influence of these parameters, in the derived measurements for cerebral autoregulation, has not yet been evaluated. In this study, cerebral autoregulation was assessed using correlation, coherence, a modified version of coherence and transfer function gain, and phase. The influence of the extra-parameters on the final scores was evaluated by means of sensitivity analysis. The methods were applied to a database of 18 neonates with measurements of MABP and tissue oxygenation index (TOI). TOI reflects changes in CBF and was measured by means of near-infrared spectroscopy.

Figures in this Article
© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Alexander Caicedo ; Gunnar Naulaers ; Petra Lemmers ; Frank van Bel ; Martin Wolf, et al.
"Detection of cerebral autoregulation by near-infrared spectroscopy in neonates: performance analysis of measurement methods", J. Biomed. Opt. 17(11), 117003 (Nov 01, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.11.117003


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