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Research Papers: Imaging

Optical microangiography provides correlation between microstructure and microvasculature of optic nerve head in human subjects

[+] Author Affiliations
Lin An

University of Washington, Departments of Bioengineering, Seattle, Washington 98195

Murray Johnstone

University of Washington, Department of Ophthalmology, Seattle, Washington 98104

Ruikang K. Wang

University of Washington, Departments of Bioengineering, Seattle, Washington 98195

University of Washington, Department of Ophthalmology, Seattle, Washington 98104

J. Biomed. Opt. 17(11), 116018 (Nov 05, 2012). doi:10.1117/1.JBO.17.11.116018
History: Received August 6, 2012; Revised October 7, 2012; Accepted October 9, 2012
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Abstract.  It is demonstrated that optical microangiography (OMAG) is capable of imaging the detailed microstructure and microvasculature of the in vivo human optic nerve head (ONH), including the prelaminar tissue, the lamina cribrosa, the scleral rim and the vessels in the region of the circle of Zin-Haller. For demonstration, an ultrahigh sensitive OMAG system operating in the 850 nm wavelength region and a 500 kHz A-scan rate resulting in a spatial resolution of 6μm were used. It was shown that OMAG provides superior results for three-dimensional imaging of the ONH compared to conventional optical coherence tomography by simultaneously recording both the microstructure and the functional microcirculation. The blood supply to the tissues of the ONH is an essential physiologic parameter needed for clinical assessment of the health of the nerve.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Lin An ; Murray Johnstone and Ruikang K. Wang
"Optical microangiography provides correlation between microstructure and microvasculature of optic nerve head in human subjects", J. Biomed. Opt. 17(11), 116018 (Nov 05, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.11.116018


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