Research Papers: Imaging

Test-retest assessment of cortical activation induced by repetitive transcranial magnetic stimulation with brain atlas-guided optical topography

[+] Author Affiliations
Fenghua Tian, Amarnath Yennu, Hanli Liu

University of Texas at Arlington, Department of Bioengineering, 500 UTA Building, Arlington, Texas

F. Andrew Kozel

University of South Florida, Department of Psychiatry and Behavioral Neurosciences, Tampa, Florida

University of Texas Southwestern Medical Center, Department of Psychiatry, Dallas, Texas

Paul E. Croarkin

University of Texas Southwestern Medical Center, Department of Psychiatry, Dallas, Texas

Mayo Clinic, Department of Psychiatry and Psychology, Rochester, Minnesota

Shawn M. McClintock, Kimberly S. Mapes, Mustafa M. Husain

University of Texas Southwestern Medical Center, Department of Psychiatry, Dallas, Texas

J. Biomed. Opt. 17(11), 116020 (Nov 07, 2012). doi:10.1117/1.JBO.17.11.116020
History: Received August 12, 2012; Revised October 2, 2012; Accepted October 9, 2012
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Abstract.  Repetitive transcranial magnetic stimulation (rTMS) is a technology that stimulates neurons with rapidly changing magnetic pulses with demonstrated therapeutic applications for various neuropsychiatric disorders. Functional near-infrared spectroscopy (fNIRS) is a suitable tool to assess rTMS-evoked brain responses without interference from the magnetic or electric fields generated by the TMS coil. We have previously reported a channel-wise study of combined rTMS/fNIRS on the motor and prefrontal cortices, showing a robust decrease of oxygenated hemoglobin concentration (Δ[HbO2]) at the sites of 1-Hz rTMS and the contralateral brain regions. However, the reliability of this putative clinical tool is unknown. In this study, we develop a rapid optical topography approach to spatially characterize the rTMS-evoked hemodynamic responses on a standard brain atlas. A hemispherical approximation of the brain is employed to convert the three-dimensional topography on the complex brain surface to a two-dimensional topography in the spherical coordinate system. The test-retest reliability of the combined rTMS/fNIRS is assessed using repeated measurements performed two to three days apart. The results demonstrate that the Δ[HbO2] amplitudes have moderate-to-high reliability at the group level; and the spatial patterns of the topographic images have high reproducibility in size and a moderate degree of overlap at the individual level.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Fenghua Tian ; F. Andrew Kozel ; Amarnath Yennu ; Paul E. Croarkin ; Shawn M. McClintock, et al.
"Test-retest assessment of cortical activation induced by repetitive transcranial magnetic stimulation with brain atlas-guided optical topography", J. Biomed. Opt. 17(11), 116020 (Nov 07, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.11.116020


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