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Research Papers: General

Measurement of the nonlinear optical response of low-density lipoprotein solutions from patients with periodontitis before and after periodontal treatment: evaluation of cardiovascular risk markers

[+] Author Affiliations
Andréa M. Monteiro, Magnus Gidlund

University of São Paulo, Institute of Biomedical Sciences, SP, Brazil. Avenida Dr. Lineu Prestes, 1703, 05508-900, São Paulo, SP Brazil

Maria A. N. Jardini

São Paulo State University, School of Dentistry of São José dos Campos, São José dos Campos, SP, Brazil. Av. Francisco José Longo, 777, 12245-000—Sao Jose dos Campos, SP, Brazil

Viviana Giampaoli

University of São Paulo, Institute of Mathematics and Statistic, SP, Brazil. Rua do Matao, 1010, 05508090—Sao Paulo, SP Brazil

Sarah Alves

Federal University of São Paulo, SP, Brasil. Rua Prof. Arthur Riedel, 275 Jardim Eldorado 09972-270—Diadema, SP Brazil

Antônio M. Figueiredo Neto

University of São Paulo, Institute of Physics, SP, Brazil. Rua do Matão, Travessa R, 187 Butantã 05315-970—Sao Paulo, SP Brazil

J. Biomed. Opt. 17(11), 115004 (Nov 08, 2012). doi:10.1117/1.JBO.17.11.115004
History: Received July 18, 2012; Revised October 19, 2012; Accepted October 22, 2012
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Abstract.  The Z-Scan (ZS) technique in the thermal regime has been used to measure the nonlinear optical response of low-density lipoprotein (LDL). The ZS technique is carried out in LDL from 40 patients with chronic periodontitis before and after three, six, and 12 months of periodontal treatment. Clinical parameters such as probing depths, bleeding on probing, total and differential white blood cells counts, lipid profiles, cytokine levels, and antibodies against oxidized LDL are also determined and compared over time. Before the treatment, the ZS experimental results reveal that the LDL particles of these patients are heavily modified. Only after 12 months of the periodontal treatment, the ZS results obtained reveal behavioral characteristics of healthy particles. This conclusion is also supported by complementary laboratorial analysis showing that the periodontal treatment induces systemic changes in several inflammatory markers.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Andréa M. Monteiro ; Maria A. N. Jardini ; Viviana Giampaoli ; Sarah Alves ; Antônio M. Figueiredo Neto, et al.
"Measurement of the nonlinear optical response of low-density lipoprotein solutions from patients with periodontitis before and after periodontal treatment: evaluation of cardiovascular risk markers", J. Biomed. Opt. 17(11), 115004 (Nov 08, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.11.115004


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