Special Section on Optical Methods of Imaging in the Skin

Photodynamic therapy in dermatology: past, present, and future

[+] Author Affiliations
Razvigor Darlenski

Tokuda Hospital-Sofia, Department of Dermatology and Venereology, 51 B Nikola Vaptsarov Building, 1407 Sofia, Bulgaria

Joachim W. Fluhr

Charité University Clinic, Department of Dermatology, Berlin, Germany

J. Biomed. Opt. 18(6), 061208 (Nov 13, 2012). doi:10.1117/1.JBO.18.6.061208
History: Received August 30, 2012; Revised October 19, 2012; Accepted October 22, 2012
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Abstract.  Photodynamic therapy (PDT) is a noninvasive therapeutic method first introduced in the field of dermatology. It is mainly used for the treatment of precancerous and superficial malignant skin tumors. Today PDT finds new applications not only for nononcologic dermatoses but also in the field of other medical specialties such as otorhinolaryngology, ophthalmology, neurology, gastroenterology, and urology. We are witnessing a broadening of the spectrum of skin diseases that are treated by PDT. Since its introduction, PDT protocol has evolved significantly in terms of increasing method efficacy and patient safety. In this era of evidence-based medicine, it is expected that much effort will be put into creating a worldwide accepted consensus on PDT. A review on the current knowledge of PDT is given, and the historical basis of the method’s evolution since its introduction in the 1900s is presented. At the end, future challenges of PDT are focused on discussing gaps that exist for research in the field.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Razvigor Darlenski and Joachim W. Fluhr
"Photodynamic therapy in dermatology: past, present, and future", J. Biomed. Opt. 18(6), 061208 (Nov 13, 2012). ; http://dx.doi.org/10.1117/1.JBO.18.6.061208


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