Research Papers: Imaging

Reflectance imaging of the human retina at 810 nm does not suffice to optimize the parameters of hydrodynamic rebalancing laser treatment

[+] Author Affiliations
Filippo Piffaretti, Jean-Pierre Ballini, Matthieu Zellweger, Georges Wagnières

Swiss Federal Institute of Technology, Medical Photonics Group, SB-ISIC, Station 6, 1015 Lausanne (EPFL), Switzerland

Roberto Perotti, Edoardo Vezzola

Save Sight Foundation, Via Golgi 4, 25087 Salò, Italy

Michel Sickenberg

Save Sight Foundation, Av. d’Ouchy 14, 1006 Lausanne, Switzerland

J. Biomed. Opt. 17(11), 116027 (Nov 22, 2012). doi:10.1117/1.JBO.17.11.116027
History: Received July 10, 2012; Revised October 16, 2012; Accepted October 17, 2012
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Abstract.  The hydrodynamic rebalancing laser (HRL) procedure is an ophthalmic therapy based on the administration of subthreshold infrared (810 nm) laser light to selected areas on the retina to treat various retina diseases. Heterogeneities of tissue response are observed, including undesired retinal damages. Variations of tissue absorbance were hypothesized to cause this uneven response. Irradiation parameters (diameter=100μm; power=1W; irradiation time: 50 to 200 ms), location and tissue response were studied in 16 patients (20 eyes, 2535 laser spots) to discover any correlation between tissue response and normalized fundus reflectance at 810 nm. The results demonstrate a complex relationship between some pathologies and occurrences of retinal damage, but no clear correlation. One possible reason is that the resolution of reflectance images is insufficient to see “small” (40 μm or less) absorption centers, particularly deep-seated ones. Additionally, tissue parameters other than variations of the fundus optical absorption influence heat diffusion and temperature increases. Monitoring or individualizing the light dose in HRL therapy, or any similar infrared diode laser-based therapy will require more sophisticated technologies, including imaging the retina’s reflectance with an improved resolution, as well as refined methods to detect complex correlations between retinal damage and specific pathologies.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Filippo Piffaretti ; Jean-Pierre Ballini ; Roberto Perotti ; Matthieu Zellweger ; Edoardo Vezzola, et al.
"Reflectance imaging of the human retina at 810 nm does not suffice to optimize the parameters of hydrodynamic rebalancing laser treatment", J. Biomed. Opt. 17(11), 116027 (Nov 22, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.11.116027


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