Research Papers: Imaging

Complex conjugate artifact-free adaptive optics optical coherence tomography of in vivo human optic nerve head

[+] Author Affiliations
Dae Yu Kim, John S. Werner, Robert J. Zawadzki

University of California Davis Eye Center, Vision Science and Advanced Retinal Imaging Laboratory, 4860 Y Street, Suite 2400, Sacramento, California 95817

J. Biomed. Opt. 17(12), 126005 (Dec 03, 2012). doi:10.1117/1.JBO.17.12.126005
History: Received July 3, 2012; Revised October 18, 2012; Accepted October 31, 2012
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Abstract.  We acquired in vivo images of the human optic nerve head (ONH) using an adaptive optics—optical coherence tomography (AO-OCT) system. In order to improve imaging of the lamina cribrosa in the ONH with high lateral resolution and sensitivity, we implemented a complex conjugate artifact-free Fourier domain OCT (Fd-OCT) acquisition scheme with a reference arm-based phase shifting method. This allowed positioning of the lamina cribrosa structures near the zero path length difference where AO-OCT imaging achieves highest sensitivity. Implementation of our complex conjugate artifact removal (CCR) method required constant phase shifts between consecutive axial scans (A-scans), generated by continuous beam path-length changes from offsetting the pivot point of the scanning mirror placed in the reference arm. Fourier transform along the transverse axis and a filtering algorithm allowed reconstruction of CCR AO-OCT images. The suppression ratio of the mirror artifact was approximately 22 dB (at 18,000 A-scans per second acquisition speed) with a paperboard test target and an optimum phase-shift value. Finally, we reconstructed the three-dimensional structure of human ONH with enhanced depth range and sensitivity using CCR AO-OCT.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Dae Yu Kim ; John S. Werner and Robert J. Zawadzki
"Complex conjugate artifact-free adaptive optics optical coherence tomography of in vivo human optic nerve head", J. Biomed. Opt. 17(12), 126005 (Dec 03, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.12.126005


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