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Research Papers: General

Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex

[+] Author Affiliations
Zhen Wang, Weihua Luo, Fangyuan Zhou, Pengcheng Li, Qingming Luo

Huazhong University of Science and Technology, Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Wuhan 430074, China

Huazhong University of Science and Technology, Key Laboratory of Biomedical Photonics of Ministry of Education, Wuhan 430074, China

J. Biomed. Opt. 17(12), 125001 (Dec 03, 2012). doi:10.1117/1.JBO.17.12.125001
History: Received March 5, 2012; Revised October 29, 2012; Accepted October 31, 2012
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Abstract.  Cerebral blood flow (CBF) is critical for the maintenance of cerebral function by guaranteed constant oxygen and glucose supply to brain. Collateral channels (CCs) are recruited to provide alternatives to CBF to ischemic regions once the primary vessel is occluded during ischemic stroke. However, the knowledge of the relationship between dynamic evolution of collateral flow and the distribution of regional blood flow remains limited. In this study, laser speckle imaging was used to assess dynamic changes of CCs and regional blood flow in a rat cortex with permanent middle cerebral artery occlusion (MCAo). We found that CCs immediately provided blood flow to ischemic territories after MCAo. More importantly, there were three kinds of dynamic changes of CCs during acute stroke: persistent CC, impermanent CC, and transient CC, respectively, related to different distributions of regional blood flow. Although there was the possible occurrence of peri-infarct depolarization (PID) during ischemia, there was no obvious significance about the onset time and duration of CCs between rats with and without PID. These results suggest that the initial arising of CCs does not ensure their persistence, and that collateral flow could be varied with distribution of regional blood flow in acute ischemic stroke, which may facilitate the understanding of collateral recruitment and promote the development of collateral therapeutics in the future.

Figures in this Article
© 2012 Society of Photo-Optical Instrumentation Engineers

Topics

Blood ; Brain

Citation

Zhen Wang ; Weihua Luo ; Fangyuan Zhou ; Pengcheng Li and Qingming Luo
"Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex", J. Biomed. Opt. 17(12), 125001 (Dec 03, 2012). ; http://dx.doi.org/10.1117/1.JBO.17.12.125001


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