Special Section on Optical Methods of Imaging in the Skin

Spectroscopic methods for the photodiagnosis of nonmelanoma skin cancer

[+] Author Affiliations
Eleni Drakaki, Theognosia Vergou, Clio Dessinioti, Alexander J. Stratigos, Christina Antoniou

University of Athens, Department of Dermatology and Photobiology, Andreas Syggros Hospital, 5, I. Dragoumi Street, 16121 Athens, Greece

Carmen Salavastru

“Carol Davila” Medical School, Clinic of Dermatology “Colentina” Clinical Hospital, Bucharest, Romania

J. Biomed. Opt. 18(6), 061221 (Dec 17, 2012). doi:10.1117/1.JBO.18.6.061221
History: Received September 28, 2012; Revised November 19, 2012; Accepted November 19, 2012
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Abstract.  The importance of dermatological noninvasive imaging techniques has increased over the last decades, aiming at diagnosing nonmelanoma skin cancer (NMSC). Technological progress has led to the development of various analytical tools, enabling the in vivo/in vitro examination of lesional human skin with the aim to increase diagnostic accuracy and decrease morbidity and mortality. The structure of the skin layers, their chemical composition, and the distribution of their compounds permits the noninvasive photodiagnosis of skin diseases, such as skin cancers, especially for early stages of malignant tumors. An important role in the dermatological diagnosis and disease monitoring has been shown for promising spectroscopic and imaging techniques, such as fluorescence, diffuse reflectance, Raman and near-infrared spectroscopy, optical coherence tomography, and confocal laser-scanning microscopy. We review the use of these spectroscopic techniques as noninvasive tools for the photodiagnosis of NMSC.

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© 2012 Society of Photo-Optical Instrumentation Engineers

Citation

Eleni Drakaki ; Theognosia Vergou ; Clio Dessinioti ; Alexander J. Stratigos ; Carmen Salavastru, et al.
"Spectroscopic methods for the photodiagnosis of nonmelanoma skin cancer", J. Biomed. Opt. 18(6), 061221 (Dec 17, 2012). ; http://dx.doi.org/10.1117/1.JBO.18.6.061221


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