JBO Letters

First human Cerenkography

[+] Author Affiliations
Antonello Enrico Spinelli, Riccardo Calandrino

San Raffaele Scientific Institute, Medical Physics Department and Centre for Experimental Imaging, Via Olgettina N. 60, Milan 20182, Italy

Marco Ferdeghini

Verona University Hospital, Nuclear Medicine Department, Piazzale Aristide Stefani 1, Verona 37126, Italy

Carlo Cavedon, Emanuele Zivelonghi

Verona University Hospital, Medical Physics Unit, Piazzale Aristide Stefani 1, Verona 37126, Italy

Alberto Fenzi, Andrea Sbarbati, Federico Boschi

University of Verona, Department of Neurological, Neuropsychological, Morphological and Motor Sciences, Strada Le Grazie 8, Verona 37134, Italy

J. Biomed. Opt. 18(2), 020502 (Jan 18, 2013). doi:10.1117/1.JBO.18.2.020502
History: Received December 4, 2012; Revised December 29, 2012; Accepted January 4, 2013
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Abstract.  Cerenkov luminescence imaging is an emerging optical preclinical modality based on the detection of Cerenkov radiation induced by beta particles when traveling though biological tissues with a velocity greater than the speed of light. We present the first human Cerenkography obtained by detecting Cerenkov radiation escaping the thyroid gland of a patient treated for hyperthyroidism. The Cerenkov light was detected using an electron multiplied charge coupled device and a conventional C-mount lens. The system set-up has been tested by using a slab of ex vivo tissue equal to a 1 cm slice of chicken breast in order to simulate optical photons attenuation. We then imaged for 2 min the head and neck region of a patient treated orally 24 h before with 550 MBq of I-131. Co-registration between photographic and Cerenkov images showed a good localization of the Cerenkov light within the thyroid region. In conclusion, we showed that it is possible to obtain a planar image of Cerenkov photons escaping from a human tissue. Cerenkography is a potential novel medical tool to image superficial organs of patients treated with beta minus radiopharmaceuticals and can be extended to the imaging of beta plus emitters.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Antonello Enrico Spinelli ; Marco Ferdeghini ; Carlo Cavedon ; Emanuele Zivelonghi ; Riccardo Calandrino, et al.
"First human Cerenkography", J. Biomed. Opt. 18(2), 020502 (Jan 18, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.2.020502


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