Research Papers: Imaging

Vessel orientation-dependent sensitivity of optoacoustic imaging using a linear array transducer

[+] Author Affiliations
Stefan Preisser, Sara Peeters, Martin Frenz, Michael Jaeger

University of Bern, Institute of Applied Physics, Sidlerstrasse 5, 3012 Bern, Switzerland

Nigel L. Bush, Jeffrey C. Bamber

Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Joint Department of Physics, Downs Road, Sutton, Surrey, SM2 5PT, United Kingdom

Institute of Cancer Research and Royal Marsden NHS Foundation Trust, CRUK-EPSRC Cancer Imaging Centre, Downs Road, Sutton, Surrey, SM2 5PT, United Kingdom

Andreas G. Gertsch-Grover

Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Joint Department of Physics, Downs Road, Sutton, Surrey, SM2 5PT, United Kingdom

Arthur E. Bailey

Scitech Instruments Inc., 2826 Crestlynn Pl., North Vancouver, BC, V7J 2S5, Canada

J. Biomed. Opt. 18(2), 026011 (Feb 06, 2013). doi:10.1117/1.JBO.18.2.026011
History: Received September 20, 2012; Revised January 3, 2013; Accepted January 14, 2013
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Abstract.  For clinical optoacoustic imaging, linear probes are preferably used because they allow versatile imaging of the human body with real-time display and free-hand probe guidance. The two-dimensional (2-D) optoacoustic image obtained with this type of probe is generally interpreted as a 2-D cross-section of the tissue just as is common in echo ultrasound. We demonstrate in three-dimensional simulations, phantom experiments, and in vivo mouse experiments that for vascular imaging this interpretation is often inaccurate. The cylindrical blood vessels emit anisotropic acoustic transients, which can be sensitively detected only if the direction of acoustic radiation coincides with the probe aperture. Our results reveal for this reason that the signal amplitude of different blood vessels may differ even if the vessels have the same diameter and initial pressure distribution but different orientation relative to the imaging plane. This has important implications for the image interpretation, for the probe guidance technique, and especially in cases when a quantitative reconstruction of the optical tissue properties is required.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Stefan Preisser ; Nigel L. Bush ; Andreas G. Gertsch-Grover ; Sara Peeters ; Arthur E. Bailey, et al.
"Vessel orientation-dependent sensitivity of optoacoustic imaging using a linear array transducer", J. Biomed. Opt. 18(2), 026011 (Feb 06, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.2.026011


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