Research Papers: Imaging

Diffuse optical tomography in the presence of a chest wall

[+] Author Affiliations
Han Y. Ban, David R. Busch, Saurav Pathak, Arjun G. Yodh

University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104-6396

Frank A. Moscatelli

Swarthmore College, Department of Physics and Astronomy, Swarthmore, Pennsylvania 19081

Manabu Machida, John C. Schotland

University of Michigan, Department of Mathematics, Ann Arbor, Michigan 48109-1043

Vadim A. Markel

University of Pennsylvania, Departments of Radiology, Bioengineering and Graduate Group in Applied Mathematics and Computational Science, Philadelphia, Pennsylvania 19104

J. Biomed. Opt. 18(2), 026016 (Feb 07, 2013). doi:10.1117/1.JBO.18.2.026016
History: Received August 8, 2012; Revised December 7, 2012; Accepted January 14, 2013
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Abstract.  Diffuse optical tomography (DOT) has been employed to derive spatial maps of physiologically important chromophores in the human breast, but the fidelity of these images is often compromised by boundary effects such as those due to the chest wall. We explore the image quality in fast, data-intensive analytic and algebraic linear DOT reconstructions of phantoms with subcentimeter target features and large absorptive regions mimicking the chest wall. Experiments demonstrate that the chest wall phantom can introduce severe image artifacts. We then show how these artifacts can be mitigated by exclusion of data affected by the chest wall. We also introduce and demonstrate a linear algebraic reconstruction method well suited for very large data sets in the presence of a chest wall.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Han Y. Ban ; David R. Busch ; Saurav Pathak ; Frank A. Moscatelli ; Manabu Machida, et al.
"Diffuse optical tomography in the presence of a chest wall", J. Biomed. Opt. 18(2), 026016 (Feb 07, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.2.026016


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