Research Papers: General

Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium

[+] Author Affiliations
Joseph L. Hollmann

Northeastern University, Department of Electrical and Computer Engineering, 409 Dana Research Center, 360 Huntington Avenue, Boston, Massachusetts 02115

Gordon Center for Subsurface Sensing and Imaging Systems, 360 Huntington Avenue, 302 Stearns Center, Boston, Massachusetts 02115

Roarke Horstmeyer, Changhuei Yang

California Institute of Technology, Department of Electrical Engineering, 1200 E. California Blvd. Mail Code 136-93, Pasadena, California 91125

Charles A. DiMarzio

Northeastern University, Department of Electrical and Computer Engineering, 409 Dana Research Center, 360 Huntington Avenue, Boston, Massachusetts 02115

Gordon Center for Subsurface Sensing and Imaging Systems, 360 Huntington Avenue, 302 Stearns Center, Boston, Massachusetts 02115

Northeastern University, Department of Mechanical and Industrial Engineering, 334 Snell Engineering Center, 360 Huntington Avenue, Boston, Massachusetts 02115

J. Biomed. Opt. 18(2), 025004 (Feb 12, 2013). doi:10.1117/1.JBO.18.2.025004
History: Received July 12, 2012; Revised January 7, 2013; Accepted January 24, 2013
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Abstract.  The effects of strong scattering in tissue limit the depth to which light may be focused. However, it has been shown that scattering may be reduced utilizing adaptive optics with a focused ultrasound (US) beam guidestar. The optical signal traveling through the US beam waist is frequency shifted and may be isolated with demodulation. This paper utilizes a multiphysics simulation to model the optical and US interactions in both synthetic tissue and random scattering media. The results illustrate that optical energy may be focused within a turbid medium utilizing a US guidestar. The results also suggest that optical energy travels preferentially along optical channels within a turbid medium.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Joseph L. Hollmann ; Roarke Horstmeyer ; Changhuei Yang and Charles A. DiMarzio
"Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium", J. Biomed. Opt. 18(2), 025004 (Feb 12, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.2.025004


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