Research Papers: Imaging

In vivo inflammation mapping of periodontal disease based on diffuse reflectance spectral imaging: a clinical study

[+] Author Affiliations
Chandra Sekhar Prasanth, Unni G. Nisha, Narayanan Subhash

Centre for Earth Science Studies, Biophotonics Laboratory, PB No. 7720, Akkulam, Thiruvananthapuram, Kerala 695031, India

Joseph Betsy, Janam Prasantila

Government Dental College, Department of Periodontics, Thiruvananthapuram, Kerala 695 011, India

Jayaraj L. Jayanthi

Division of Surgical Oncology, Regional Cancer Center, Thiruvananthapuram, Kerala 695 011, India

J. Biomed. Opt. 18(2), 026019 (Feb 12, 2013). doi:10.1117/1.JBO.18.2.026019
History: Received September 21, 2012; Revised January 10, 2013; Accepted January 22, 2013
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Abstract.  Since conventional techniques using periodontal probes have inherent drawbacks in the diagnosis of different grades of gingival inflammation, development of noninvasive screening devices becomes significant. Diffuse reflectance (DR) spectra recorded with white light illumination is utilized to detect periodontal inflammation from the oxygenated hemoglobin absorption ratio R620/R575. A multispectral imaging system is utilized to record narrow-band DR images at 575 and 620 nm from the anterior sextant of the gingivia of 15 healthy volunteers and 25 patients (N=40). An experienced periodontist assesses the level of gingival inflammation at each site through periodontal probing and assigns diagnosis as healthy, mild, moderate, or severe inflammation. The DR image ratio R620/R575 computed for each pixel (8-µm resolution) from the monochrome images is pseudo-color-mapped to identify gingival inflammation sites. The DR image ratio values at each site are compared with clinical diagnosis to estimate the specificity and sensitivity of the DR imaging technique in inflammation mapping. The high diagnostic accuracy is utilized to detect underlying inflammation in six patients with a previous history of periodontitis.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Chandra Sekhar Prasanth ; Joseph Betsy ; Jayaraj L. Jayanthi ; Unni G. Nisha ; Janam Prasantila, et al.
"In vivo inflammation mapping of periodontal disease based on diffuse reflectance spectral imaging: a clinical study", J. Biomed. Opt. 18(2), 026019 (Feb 12, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.2.026019


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