Research Papers: Imaging

Color-matched and fluorescence-labeled esophagus phantom and its applications

[+] Author Affiliations
Chenying Yang

University of Washington, Department of Bioengineering, 204 Fluke Hall, 4000 Mason Road, Seattle, Washington 98195

Vivian Hou

University of Washington, Department of Biology, Seattle, Washington 98195

Leonard Y. Nelson, Eric J. Seibel

University of Washington, Department of Mechanical Engineering, Seattle, Washington 98195

J. Biomed. Opt. 18(2), 026020 (Feb 12, 2013). doi:10.1117/1.JBO.18.2.026020
History: Received November 20, 2012; Revised January 22, 2013; Accepted January 23, 2013
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Abstract.  We developed a stable, reproducible three-dimensional optical phantom for the evaluation of a wide-field endoscopic molecular imaging system. This phantom mimicked a human esophagus structure with flexibility to demonstrate body movements. At the same time, realistic visual appearance and diffuse spectral reflectance properties of the tissue were simulated by a color matching methodology. A photostable dye-in-polymer technology was applied to represent biomarker probed “hot-spot” locations. Furthermore, fluorescent target quantification of the phantom was demonstrated using a 1.2 mm ultrathin scanning fiber endoscope with concurrent fluorescence-reflectance imaging.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Chenying Yang ; Vivian Hou ; Leonard Y. Nelson and Eric J. Seibel
"Color-matched and fluorescence-labeled esophagus phantom and its applications", J. Biomed. Opt. 18(2), 026020 (Feb 12, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.2.026020


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