JBO Letters

Compact high power barium nitrite crystal-based Raman laser at 1197 nm for photoacoustic imaging of fat

[+] Author Affiliations
Rui Li, Mikhail N. Slipchenko, Pu Wang, Ji-Xin Cheng

Purdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana 47907

J. Biomed. Opt. 18(4), 040502 (Mar 27, 2013). doi:10.1117/1.JBO.18.4.040502
History: Received November 9, 2012; Revised February 16, 2013; Accepted March 6, 2013
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Abstract.  Photoacoustic imaging employing molecular overtone vibration as a contrast mechanism opens a new avenue for bond-selective imaging of deep tissues. Broad use of this modality is, however, hampered by the extremely low conversion efficiency of optical parametric oscillators at the overtone transition wavelengths. To overcome such a barrier, we demonstrate the construction and use of a compact, barium nitrite crystal-based Raman laser for photoacoustic imaging of CH overtone vibrations. Using a 5-ns NdYAG laser as the pumping source, up to 21.4 mJ pulse energy at 1197 nm was generated, corresponding to a conversion efficiency of 34.8%. Using the 1197 nm pulses, three-dimensional photoacoustic imaging of intramuscular fat was demonstrated.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Rui Li ; Mikhail N. Slipchenko ; Pu Wang and Ji-Xin Cheng
"Compact high power barium nitrite crystal-based Raman laser at 1197 nm for photoacoustic imaging of fat", J. Biomed. Opt. 18(4), 040502 (Mar 27, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.4.040502


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