Research Papers: Imaging

Modulation of photoacoustic signal generation from metallic surfaces

[+] Author Affiliations
Trevor Mitcham, John Hazle, Richard Bouchard

University of Texas MD Anderson Cancer Center, Department of Imaging Physics, 1881 East Road Unit 1902, Houston, Texas 77054

Kimberly Homan, Wolfgang Frey, Yun-Sheng Chen

University of Texas at Austin, Department of Biomedical Engineering, 1 University Station C0800, Austin, Texas 78712

Stanislav Emelianov

University of Texas MD Anderson Cancer Center, Department of Imaging Physics, 1881 East Road Unit 1902, Houston, Texas 77054

University of Texas at Austin, Department of Biomedical Engineering, 1 University Station C0800, Austin, Texas 78712

J. Biomed. Opt. 18(5), 056008 (May 07, 2013). doi:10.1117/1.JBO.18.5.056008
History: Received December 20, 2012; Revised March 20, 2013; Accepted April 4, 2013
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Abstract.  The ability to image metallic implants is important for medical applications ranging from diagnosis to therapy. Photoacoustic (PA) imaging has been recently pursued as a means to localize metallic implants in soft tissue. The work presented herein investigates different mechanisms to modulate the PA signal generated by macroscopic metallic surfaces. Wires of five different metals are tested to simulate medical implants/tools, while surface roughness is altered or physical vapor deposition (PVD) coatings are added to change the wires’ overall optical absorption. PA imaging data of the wires are acquired at 970 nm. Results indicate that PA signal generation predominately occurs in a wire’s metallic surface and not its aqueous surroundings. PA signal generation is similar for all metals tested, while addition of PVD coatings offers significant modulations (i.e., 4-dB enhancement and 26-dB reduction achieved) in PA signal generation. Results also suggest that PA signal increases with increasing surface roughness. Different coating and roughness schemes are then successfully utilized to generate spatial PA signal patterns. This work demonstrates the potential of surface modifications to enhance or reduce PA signal generation to permit improved PA imaging of implants/tools (i.e., providing location/orientation information) or to allow PA imaging of surrounding tissue.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Trevor Mitcham ; Kimberly Homan ; Wolfgang Frey ; Yun-Sheng Chen ; Stanislav Emelianov, et al.
"Modulation of photoacoustic signal generation from metallic surfaces", J. Biomed. Opt. 18(5), 056008 (May 07, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.5.056008


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