Research Papers: Sensing

Diffuse optical characterization of an exercising patient group with peripheral artery disease

[+] Author Affiliations
Rickson C. Mesquita

University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104

University of Campinas, Institute of Physics, Campinas, SP 13083-859, Brazil

Mary Putt, Sung Wan Han

University of Pennsylvania, Department of Biostatistics and Epidemiology, Philadelphia, Pennsylvania 19104

Malavika Chandra, Xiaoman Xing, Arjun G. Yodh

University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104

Guoqiang Yu, Yu Shang

University of Kentucky, Center for Biomedical Engineering, Lexington, Kentucky 40506

Gwen Lech

University of Pennsylvania, School of Nursing, Philadelphia, Pennsylvania 19104

Turgut Durduran

ICFO-Institut de Ciències Fotòniques, Mediterranean Technology Park, 08860 Castelldefels (Barcelona), Spain

Chao Zhou

Lehigh University, Department of Electrical and Computer Engineering, Bethlehem, Pennsylvania 18015

Emile R. Mohler

University of Pennsylvania, Perelman School of Medicine, Department of Medicine, Cardiovascular Division, Section of Vascular Medicine, Philadelphia, Pennsylvania 19104

J. Biomed. Opt. 18(5), 057007 (May 24, 2013). doi:10.1117/1.JBO.18.5.057007
History: Received December 19, 2012; Revised April 7, 2013; Accepted April 19, 2013
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Abstract.  Peripheral artery disease (PAD) is a common condition with high morbidity. While measurement of tissue oxygen saturation (StO2) has been demonstrated, this is the first study to assess both StO2 and relative blood flow (rBF) in the extremities of PAD patients. Diffuse optics is employed to measure hemodynamic response to treadmill and pedal exercises in 31 healthy controls and 26 patients. For StO2, mild and moderate/severe PAD groups show pronounced differences compared with controls. Pre-exercise mean StO2 is lower in PAD groups by 9.3% to 10.6% compared with means of 63.5% to 66.2% in controls. For pedal, relative rate of return of StO2 to baseline is more rapid in controls (p<0.05). Patterns of rBF also differ among groups. After both exercises, rBF tend to occur at depressed levels among severe PAD patients compared with healthy (p<0.05); post-treadmill, rBF tend to occur at elevated levels among healthy compared with severe PAD patients (p<0.05). Additionally, relative rate of return to baseline StO2 is more rapid among subjects with reduced levels of depression in rBF (p=0.041), even after adjustment for ankle brachial index. This suggests a physiologic connection between rBF and oxygenation that can be measured using diffuse optics, and potentially employed as an evaluative tool in further studies.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Rickson C. Mesquita ; Mary Putt ; Malavika Chandra ; Guoqiang Yu ; Xiaoman Xing, et al.
"Diffuse optical characterization of an exercising patient group with peripheral artery disease", J. Biomed. Opt. 18(5), 057007 (May 24, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.5.057007


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