Special Section on Fluorescence Molecular Imaging Honoring Prof. Roger Tsien, a Pioneer in Biomedical Optics

Concurrent video-rate color and near-infrared fluorescence laparoscopy

[+] Author Affiliations
Jürgen Glatz

Technical University Munich, Chair for Biological Imaging, Munich, Germany

Júlia Varga, Florian R. Greten

Technical University Munich, 2nd Department of Medicine, Klinikum rechts der Isar, Munich, Germany

Pilar Beatriz Garcia-Allende, Maximilian Koch

Helmholtz Zentrum München, Institute for Biological and Medical Imaging, Oberschleißheim, Germany

Vasilis Ntziachristos

Technical University Munich, Chair for Biological Imaging, Munich, Germany

Helmholtz Zentrum München, Institute for Biological and Medical Imaging, Oberschleißheim, Germany

J. Biomed. Opt. 18(10), 101302 (May 29, 2013). doi:10.1117/1.JBO.18.10.101302
History: Received January 29, 2013; Revised March 25, 2013; Accepted April 8, 2013
Text Size: A A A

Abstract.  The visual identification and demarcation of tumors and tumor margins remains challenging due to the low optical contrast of cancer cells over surrounding tissues. Fluorescence molecular imaging was recently considered clinically for improving cancer detection during open surgery. We present herein a next step in the development of fluorescence molecular guidance by describing a novel video-rate imaging laparoscope capable of concurrently recording color and near-infrared fluorescence images and video. Video-rate operation is based on graphics processing unit-based image processing. We examine the optical characteristics of the system developed and provide performance metrics related to intra-operative endoscopic guidance, showcased on phantoms and endoscopic color and fluorescence molecular imaging of tumors in a mouse model of the human disease.

Figures in this Article
© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Jürgen Glatz ; Júlia Varga ; Pilar Beatriz Garcia-Allende ; Maximilian Koch ; Florian R. Greten, et al.
"Concurrent video-rate color and near-infrared fluorescence laparoscopy", J. Biomed. Opt. 18(10), 101302 (May 29, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.10.101302


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.