Research Papers: Imaging

En face parametric imaging of tissue birefringence using polarization-sensitive optical coherence tomography

[+] Author Affiliations
Lixin Chin, Xiaojie Yang, Robert A. McLaughlin

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical + Biomedical Engineering Laboratory, M018, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Peter B. Noble

The University of Western Australia, School of Anatomy, Physiology and Human Biology, M309, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

The University of Western Australia, School of Paediatrics and Child Health, Centre for Neonatal Research and Education, M550, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

David D. Sampson

The University of Western Australia, School of Electrical, Electronic and Computer Engineering, Optical + Biomedical Engineering Laboratory, M018, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

The University of Western Australia, Centre for Microscopy, Characterisation and Analysis, M018, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

J. Biomed. Opt. 18(6), 066005 (Jun 03, 2013). doi:10.1117/1.JBO.18.6.066005
History: Received January 31, 2013; Revised April 29, 2013; Accepted May 1, 2013
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Abstract.  A technique for generating en face parametric images of tissue birefringence from scans acquired using a fiber-based polarization-sensitive optical coherence tomography (PS-OCT) system utilizing only a single-incident polarization state is presented. The value of birefringence is calculated for each A-scan in the PS-OCT volume using a quadrature demodulation and phase unwrapping algorithm. The algorithm additionally uses weighted spatial averaging and weighted least squares regression to account for the variation in phase accuracies due to varying OCT signal-to-noise-ratio. The utility of this technique is demonstrated using a model of thermally induced damage in porcine tendon and validated against histology. The resulting en face images of tissue birefringence are more useful than conventional PS-OCT B-scans in assessing the severity of tissue damage and in localizing the spatial extent of damage.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Lixin Chin ; Xiaojie Yang ; Robert A. McLaughlin ; Peter B. Noble and David D. Sampson
"En face parametric imaging of tissue birefringence using polarization-sensitive optical coherence tomography", J. Biomed. Opt. 18(6), 066005 (Jun 03, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.6.066005


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