Special Section on Advanced Biomedical Imaging and Sensing

Detection of melamine on fractals of unmodified gold nanoparticles by surface-enhanced Raman scattering

[+] Author Affiliations
Pradip Kumar Roy, Yi-Fan Huang

National Yang-Ming University, Institute of Biophotonics, Taipei 112, Taiwan

Surojit Chattopadhyay

National Yang-Ming University, Institute of Biophotonics, Taipei 112, Taiwan

National Yang Ming University, Biophotonics and Molecular Imaging Research Centre, Taipei-112, Taiwan

J. Biomed. Opt. 19(1), 011002 (Jun 10, 2013). doi:10.1117/1.JBO.19.1.011002
History: Received February 7, 2013; Revised March 27, 2013; Accepted April 11, 2013
Text Size: A A A

Abstract.  A simple way of detecting melamine in raw milk is demonstrated via surface-enhanced Raman spectroscopy (SERS) using fractals of bare and nonfunctionalized 30nm gold nanoparticles (AuNP) distributed on a solid support. The technique demonstrates the formation of AuNP fractals, from a random distribution, upon exposure to melamine, that enhance the Raman scattering cross-section to enable detection by SERS. The agglomeration, which is pronounced at higher melamine concentrations, is demonstrated directly through imaging, and the red-shift of the plasmon absorption peak of the AuNP fractal away from 530 nm by finite difference time domain (FDTD) calculations. The agglomeration results in a strong plasmon field, shown by FDTD, over the interparticle sites that enhances the Raman scattering cross-section of melamine and ensures unambiguous detection. Limit of detection of 100 ppb could be achieved reproducibly.

Figures in this Article
© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Pradip Kumar Roy ; Yi-Fan Huang and Surojit Chattopadhyay
"Detection of melamine on fractals of unmodified gold nanoparticles by surface-enhanced Raman scattering", J. Biomed. Opt. 19(1), 011002 (Jun 10, 2013). ; http://dx.doi.org/10.1117/1.JBO.19.1.011002


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.