Research Papers: Imaging

Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity

[+] Author Affiliations
John Quan Nguyen, Christian Crouzet, Tuan Mai, Kathleen Riola, Daniel Uchitel, Lih-Huei Liaw, Adrien Ponticorvo, Bernard Choi, Anthony J. Durkin

Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road, Irvine, California 92617-3010

Nicole Bernal

UC Irvine Regional Burn Center, Department of Surgery, 333 City Boulevard West, Suite 705, Orange, California 92868

J. Biomed. Opt. 18(6), 066010 (Jun 13, 2013). doi:10.1117/1.JBO.18.6.066010
History: Received March 28, 2013; Revised May 9, 2013; Accepted May 14, 2013
Text Size: A A A

Abstract.  Frequent monitoring of early-stage burns is necessary for deciding optimal treatment and management. Both superficial and full thickness burns are relatively easy to diagnose based on clinical observation. In between these two extremes are superficial-partial thickness and deep-partial thickness burns. These burns, while visually similar, differ dramatically in terms of clinical treatment and are known to progress in severity over time. The objective of this study was to determine the potential of spatial frequency domain imaging (SFDI) for noninvasively mapping quantitative changes in chromophore and optical properties that may be an indicative of burn wound severity. A controlled protocol of graded burn severity was developed and applied to 17 rats. SFDI data was acquired at multiple near-infrared wavelengths over a course of 3 h. Burn severity was verified using hematoxylin and eosin histology. From this study, we found that changes in water concentration (edema), deoxygenated hemoglobin concentration, and optical scattering (tissue denaturation) to be statistically significant at differentiating superficial partial-thickness burns from deep-partial thickness burns.

Figures in this Article
© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

John Quan Nguyen ; Christian Crouzet ; Tuan Mai ; Kathleen Riola ; Daniel Uchitel, et al.
"Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity", J. Biomed. Opt. 18(6), 066010 (Jun 13, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.6.066010


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.