JBO Letters

Motion-contrast laser speckle imaging of microcirculation within tissue beds in vivo

[+] Author Affiliations
Rong Liu

University of Washington, Department of Bioengineering, Seattle, Washington 98195

Tianjin University, State Key Laboratory of Precision Measuring Technology and Instruments, Tianjin 300072, China

Jia Qin, Ruikang K. Wang

University of Washington, Department of Bioengineering, Seattle, Washington 98195

J. Biomed. Opt. 18(6), 060508 (Jun 26, 2013). doi:10.1117/1.JBO.18.6.060508
History: Received April 10, 2013; Revised May 9, 2013; Accepted May 17, 2013
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Abstract.  Laser speckle imaging is widely used to monitor functional blood perfusion within tissue beds in vivo but traditionally has difficulty visualizing small blood vessels even when the exposure time of the detector is long. We report a simple method that uses the motion contrast of dynamic speckle patterns to noninvasively visualize the distribution of blood flow within tissue beds in vivo. We experimentally demonstrate that the motion contrast can significantly suppress the effect of static scattering, leading to enhanced visibility of the functional blood vessels, including capillaries when compared to the traditional laser speckle contrast imaging.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Rong Liu ; Jia Qin and Ruikang K. Wang
"Motion-contrast laser speckle imaging of microcirculation within tissue beds in vivo", J. Biomed. Opt. 18(6), 060508 (Jun 26, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.6.060508


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