Research Papers: General

New model of subconjunctival tumor development in rabbits

[+] Author Affiliations
Sang Seok Hwang, Jeong Eun Kim, Yeh-Chan Ahn

Pukyong National University, Department of Biomedical Engineering/Interdisciplinary Program of Medical Biotechnology Application Engineering, Busan 608-737, Republic of Korea

Bong-Kwon Chun

Kosin University College of Medicine, Department of Pathology, Busan 602-702, Republic of Korea

Kosin University College of Medicine, Institute for Global Health and Environment Cooperation, Busan 602-702, Republic of Korea

Sangbong Jung

Gimhae College, Department of Clinical Laboratory Science, Gimhae 621-706, Republic of Korea

Eun-Kee Park

Kosin University College of Medicine, Institute for Global Health and Environment Cooperation, Busan 602-702, Republic of Korea

Kosin University College of Medicine, Department of Medical Humanities and Social Medicine, Busan 602-702, Republic of Korea

Hu-Jang Lee

Gyeongsang National University, College of Veterinary Medicine, Research Institute of Life Sciences, Chinju 660-701, Republic of Korea

Mannhong Jung

Kosin University College of Medicine, Department of Internal Medicine, Busan 602-702, Republic of Korea

Sang-Joon Lee, Gwang Myung Noh

Kosin University College of Medicine, Department of Ophthalmology, Busan 602-702, Republic of Korea

Rangarirai Masanganise

University of Zimbabwe, College of Medicine, Department of Ophthalmology, Harare, Zimbabwe

Chulho Oak

Kosin University College of Medicine, Institute for Global Health and Environment Cooperation, Busan 602-702, Republic of Korea

Kosin University College of Medicine, Department of Internal Medicine, Busan 602-702, Republic of Korea

J. Biomed. Opt. 18(7), 070501 (Jul 01, 2013). doi:10.1117/1.JBO.18.7.070501
History: Received March 23, 2013; Revised May 20, 2013; Accepted May 20, 2013
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Abstract.  Conjunctival squamous cell carcinoma (SCC) is an uncommon disease. However, SCC has recently become an important clinical problem due the identification of a significantly high incidence of SCC among a group of black African patients with AIDS. However, basic research concerning SCC, including both intraepithelial and invasive squamous neoplasia, is limited due to the lack of an ocular tumor animal model. Specifically, current ocular imaging and treatment modalities are insufficient for investigating currently available small animal models, because the conjunctival space is not comparable to that of humans. We describe the development of a reproducible model of subconjunctival squamous carcinoma in moderate-sized immunocompetent rabbits. Under optical coherence tomography guidance, 1×107 VX2 carcinoma cells are inoculated into the subconjunctival space of 3 to 4-kg New Zealand white rabbits. Malignant tumor involvement developed on the subconjunctival space after an average of 1 to 2 weeks. This subconjunctival tumor model induction method will likely facilitate a broad range of investigation of subconjunctival cancer diagnostics and therapeutics.

Figures in this Article
© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Sang Seok Hwang ; Jeong Eun Kim ; Bong-Kwon Chun ; Sangbong Jung ; Eun-Kee Park, et al.
"New model of subconjunctival tumor development in rabbits", J. Biomed. Opt. 18(7), 070501 (Jul 01, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.7.070501


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