The synthesis of o-BMVC is briefly described in Fig. 1. 3,6-Dibromocarbazole (10 mmole, Aldrich, St. Louis, MO) was added into a high-pressure bottle containing the mixture of palladium(II) acetate (25 mg, Strem, Newburyport, MA) and tri-o-tolyl phosphine (250 mg, Aldrich). To this, the solvent pair (tri-ethylamine 15 ml/acetonitrile 45 ml) and 2-vinylpyridine (30 mmole, Merck, Darmstadt, Germany) were added. The bottle was sealed after bubbling 10 min with nitrogen. After keeping the system under for two days, the precipitant was collected and then extracted with twice. The insoluble solids in the layer were filtered, collected, and washed with hot tetrahydrofuran (THF); then the filtrates were dried by . Crude powder was purified by flash column chromatography with acetone/n-hexane as eluent gradient to collect the yellow powder, precursor of o-BMVC (compound 2, shown in Fig. 1). Yield: 72%, melting point (mp): 254 to 256°C, molecular weight (Mw): 373. NMR [dimethyl sulfoxide (DMSO-d6)]: (s, 1H, NH), 8.57 (dd, , 1.38 Hz, 2H), 8.48 (s, 2H), 7.85 (d, , 2H), 7.78 (m, 2H), 7.74 (dd, , 1.26 Hz, 2H), 7.55 (d, , 2H), 7.50 (d, , 2H), 7.31 (d, , 2H), 7.23 (dd, , 6.4 Hz, 2H). After refluxing compound 2 with excess in THF/dimethylformamide (DMF) () for 4 h, the orange powder, o-BMVC, was collected with a hot filter (Yield: 95%, mp , Mw: 657). Data for o-BMVC: NMR (DMSO-d6): (s, 1H, NH), 8.87 (dd, , 1.2 Hz, 2H), 8.84 (s, 2H), 8.47 (d, , 2H), 4,42 (s, 6H), ESI/MS ( 201.68 (exclude ), element analysis (): calc (obs%) C: 49.12 (49.17), H: 4.09 (4.03), N: 6.14 (6.12).