Research Papers: General

Dynamic model of thermal reaction of biological tissues to laser-induced fluorescence and photodynamic therapy

[+] Author Affiliations
Alexey Yu. Seteikin

Kwangwoon University, Electrophysics Department, Wolgye-Dong 447-1, Nowon-GU, 139701 Seoul, Republic of Korea

Amur State University, Physics Department, Ignat’evskoe shosse 21, 675027 Blagoveshchensk, Russia

Ilya V. Krasnikov

Amur State University, Physics Department, Ignat’evskoe shosse 21, 675027 Blagoveshchensk, Russia

Eleni Drakaki, Mersini Makropoulou

National Technical University of Athens, School of Applied Mathematical and Physical Sciences, Physics Department, Zografou Campus, 15780 Athens, Greece

J. Biomed. Opt. 18(7), 075002 (Jul 09, 2013). doi:10.1117/1.JBO.18.7.075002
History: Received December 13, 2012; Revised June 8, 2013; Accepted June 11, 2013
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Abstract.  The aim of this work was to evaluate the temperature fields and the dynamics of heat conduction into the skin tissue under several laser irradiation conditions with both a pulsed ultraviolet (UV) laser (λ=337nm) and a continuous-wave (cw) visible laser beam (λ=632.8nm) using Monte Carlo modeling. Finite-element methodology was used for heat transfer simulation. The analysis of the results showed that heat is not localized on the surface, but is collected inside the tissue in lower skin layers. The simulation was made with the pulsed UV laser beam (used as excitation source in laser-induced fluorescence) and the cw visible laser (used in photodynamic therapy treatments), in order to study the possible thermal effects.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Alexey Yu. Seteikin ; Ilya V. Krasnikov ; Eleni Drakaki and Mersini Makropoulou
"Dynamic model of thermal reaction of biological tissues to laser-induced fluorescence and photodynamic therapy", J. Biomed. Opt. 18(7), 075002 (Jul 09, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.7.075002


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