Research Papers: Imaging

Small-animal radionuclide luminescence imaging of thyroid and salivary glands with Tc99m-pertechnetate

[+] Author Affiliations
Federico Boschi, Maria Paola Cecchini

University of Verona, Department of Neurological, Neuropsychological, Morphological and Motor Sciences, Strada Le Grazie 8, 37134 Verona, Italy

Marco Pagliazzi, Antonello E. Spinelli

San Raffaele Scientific Institute, Medical Physics Department and Centre for Experimental Imaging, Via Olgettina 60, Milan, Italy

Barbara Rossi

University of Verona, Department of Pathology and Diagnostics, Strada Le Grazie 8, 37134 Verona, Italy

Giancarlo Gorgoni, Matteo Salgarello

Ospedale Sacro Cuore Don Calabria, Nuclear Medicine Department, Via Sempreboni, 5-37024 Negrar (Verona), Italy

J. Biomed. Opt. 18(7), 076005 (Jul 10, 2013). doi:10.1117/1.JBO.18.7.076005
History: Received April 4, 2013; Revised May 20, 2013; Accepted May 21, 2013
Text Size: A A A

Abstract.  The in vitro and in vivo detection of visible photons from radioisotopes using optical techniques is a fast-growing field in molecular imaging. Tc99m-pertechnetate is used as an alternative to I123 in imaging of the thyroid and is generally imaged with gamma cameras or single photon emission tomography instruments. The uptake in the thyroid tissue is mediated by the sodium-iodide symporter (NIS), a glycoprotein that actively mediates iodide transport into the thyroid follicular cells and several extrathyroidal tissues. The luminescence of the gamma emitter Tc99m-pertechnetate in order to visualize its biodistribution in healthy small living animals by using a commercial optical imaging system is investigated. Here we show that in Nu/Nu mice, the uptake of Tc99m-pertechnetate in the thyroid gland and in salivary glands is very detectable by using radionuclide luminescence imaging. We also found light emission from the stomach in accordance with the literature. The localization of the light signals in the anatomical regions where the radiopharmaceutical is expected, confirmed by resections, shows that it is possible to image NIS-expressing tissues.

Figures in this Article
© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Federico Boschi ; Marco Pagliazzi ; Barbara Rossi ; Maria Paola Cecchini ; Giancarlo Gorgoni, et al.
"Small-animal radionuclide luminescence imaging of thyroid and salivary glands with Tc99m-pertechnetate", J. Biomed. Opt. 18(7), 076005 (Jul 10, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.7.076005


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.