Research Papers: Imaging

Pilot study assessment of dynamic vascular changes in breast cancer with near-infrared tomography from prospectively targeted manipulations of inspired end-tidal partial pressure of oxygen and carbon dioxide

[+] Author Affiliations
Shudong Jiang, Brian W. Pogue, Kelly E. Michaelsen, Michael Jermyn, Michael A. Mastanduno, Keith D. Paulsen

Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755

Tracy E. Frazee, Peter A. Kaufman

Dartmouth-Hitchcock Medical Center, Department of Medicine, Lebanon, New Hampshire 03766

J. Biomed. Opt. 18(7), 076011 (Jul 10, 2013). doi:10.1117/1.JBO.18.7.076011
History: Received April 4, 2013; Revised May 16, 2013; Accepted June 11, 2013
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Abstract.  The dynamic vascular changes in the breast resulting from manipulation of both inspired end-tidal partial pressure of oxygen and carbon dioxide were imaged using a 30 s per frame frequency-domain near-infrared spectral (NIRS) tomography system. By analyzing the images from five subjects with asymptomatic mammography under different inspired gas stimulation sequences, the mixture that maximized tissue vascular and oxygenation changes was established. These results indicate maximum changes in deoxy-hemoglobin, oxygen saturation, and total hemoglobin of 21, 9, and 3%, respectively. Using this inspired gas manipulation sequence, an individual case study of a subject with locally advanced breast cancer undergoing neoadjuvant chemotherapy (NAC) was analyzed. Dynamic NIRS imaging was performed at different time points during treatment. The maximum tumor dynamic changes in deoxy-hemoglobin increased from less than 7% at cycle 1, day 5 (C1, D5) to 17% at (C1, D28), which indicated a complete response to NAC early during treatment and was subsequently confirmed pathologically at the time of surgery.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Shudong Jiang ; Brian W. Pogue ; Kelly E. Michaelsen ; Michael Jermyn ; Michael A. Mastanduno, et al.
"Pilot study assessment of dynamic vascular changes in breast cancer with near-infrared tomography from prospectively targeted manipulations of inspired end-tidal partial pressure of oxygen and carbon dioxide", J. Biomed. Opt. 18(7), 076011 (Jul 10, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.7.076011


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