Special Section on Optical Imaging, Sensing, and Light Interactions in Cells and Tissues

Microvascular anastomosis guidance and evaluation using real-time three-dimensional Fourier-domain Doppler optical coherence tomography

[+] Author Affiliations
Yong Huang, Jin U. Kang

Johns Hopkins University, Department of Electrical and Computer Engineering, 3400 N. Charles Street, Baltimore, Maryland 21218

Zuhaib Ibrahim, Qi Mao, John Pang, Wei Ping Andrew Lee, Gerald Brandacher

Johns Hopkins University, Department of Plastic and Reconstructive Surgery, School of Medicine, 733 N. Broadway, Baltimore, Maryland

Dedi Tong

Johns Hopkins University, Department of Electrical and Computer Engineering, 3400 N. Charles Street, Baltimore, Maryland 21218

Beijing Jishuitan Hospital, Department of Hand Surgery, 31 Xinjiekou East Street, Xicheng District, Beijing, 10035 China

Shan Zhu

Johns Hopkins University, Department of Plastic and Reconstructive Surgery, School of Medicine, 733 N. Broadway, Baltimore, Maryland

Peking Union Medical College and Chinese Academy of Medical Sciences, Department of Plastic and Reconstructive Surgery, Plastic Surgery Hospital, 3 Ba-Da-Chu Road, Shijingshan District, Beijing, 10044 China

J. Biomed. Opt. 18(11), 111404 (Jul 15, 2013). doi:10.1117/1.JBO.18.11.111404
History: Received March 1, 2013; Revised May 20, 2013; Accepted June 13, 2013
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Abstract.  Vascular and microvascular anastomoses are critical components of reconstructive microsurgery, vascular surgery, and transplant surgery. Intraoperative surgical guidance using a surgical imaging modality that provides an in-depth view and three-dimensional (3-D) imaging can potentially improve outcome following both conventional and innovative anastomosis techniques. Objective postoperative imaging of the anastomosed vessel can potentially improve the salvage rate when combined with other clinical assessment tools, such as capillary refill, temperature, blanching, and skin turgor. Compared to other contemporary postoperative monitoring modalities—computed tomography angiograms, magnetic resonance (MR) angiograms, and ultrasound Doppler—optical coherence tomography (OCT) is a noninvasive high-resolution (micron-level), high-speed, 3-D imaging modality that has been adopted widely in biomedical and clinical applications. For the first time, to the best of our knowledge, the feasibility of real-time 3-D phase-resolved Doppler OCT (PRDOCT) as an assisted intra- and postoperative imaging modality for microvascular anastomosis of rodent femoral vessels is demonstrated, which will provide new insights and a potential breakthrough to microvascular and supermicrovascular surgery.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Yong Huang ; Zuhaib Ibrahim ; Dedi Tong ; Shan Zhu ; Qi Mao, et al.
"Microvascular anastomosis guidance and evaluation using real-time three-dimensional Fourier-domain Doppler optical coherence tomography", J. Biomed. Opt. 18(11), 111404 (Jul 15, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.11.111404


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