Research Papers: Imaging

Use of Split Bregman denoising for iterative reconstruction in fluorescence diffuse optical tomography

[+] Author Affiliations
Judit Chamorro-Servent, Juan F. P. J. Abascal, Jorge Ripoll, Juan J. Vaquero

Universidad Carlos III de Madrid, Departamento de Bioingeniería e Ingeniería Aeroespacial, 28911 Leganés, Spain

Instituto de Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain

Juan Aguirre

Centro de Investigación Biomédica en Red de Salud Mental, 28007 Madrid, Spain

Simon Arridge, Teresa Correia

University College London, Department of Computer Science, London WC1E 6BT, United Kingdom

Manuel Desco

Universidad Carlos III de Madrid, Departamento de Bioingeniería e Ingeniería Aeroespacial, 28911 Leganés, Spain

Instituto de Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain

Centro de Investigación Biomédica en Red de Salud Mental, 28007 Madrid, Spain

J. Biomed. Opt. 18(7), 076016 (Jul 17, 2013). doi:10.1117/1.JBO.18.7.076016
History: Received April 12, 2013; Revised June 6, 2013; Accepted June 17, 2013
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Abstract.  Fluorescence diffuse optical tomography (fDOT) is a noninvasive imaging technique that makes it possible to quantify the spatial distribution of fluorescent tracers in small animals. fDOT image reconstruction is commonly performed by means of iterative methods such as the algebraic reconstruction technique (ART). The useful results yielded by more advanced l1-regularized techniques for signal recovery and image reconstruction, together with the recent publication of Split Bregman (SB) procedure, led us to propose a new approach to the fDOT inverse problem, namely, ART-SB. This method alternates a cost-efficient reconstruction step (ART iteration) with a denoising filtering step based on minimization of total variation of the image using the SB method, which can be solved efficiently and quickly. We applied this method to simulated and experimental fDOT data and found that ART-SB provides substantial benefits over conventional ART.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Judit Chamorro-Servent ; Juan F. P. J. Abascal ; Juan Aguirre ; Simon Arridge ; Teresa Correia, et al.
"Use of Split Bregman denoising for iterative reconstruction in fluorescence diffuse optical tomography", J. Biomed. Opt. 18(7), 076016 (Jul 17, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.7.076016


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