Research Papers: Sensing

Optical detection of gold nanoparticles in a prostate-shaped porcine phantom

[+] Author Affiliations
Serge Grabtchak

University of Prince Edward Island, Department of Physics, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3, Canada

Dalhousie University, Department of Electrical and Computer Engineering, 1459 Oxford Street, Halifax, Nova Scotia B3H 4R2, Canada

Dalhousie University, Department of Physics, 6310 Coburg Road, Halifax, Nova Scotia B3H 4R2, Canada

Elena Tonkopi

QEII Health Sciences Centre – Victoria General Hospital Site, Department of Diagnostic Imaging, 1276 South Park Street, Halifax, Nova Scotia B3H 2Y9, Canada

Dalhousie University, Department of Radiology, P.O. Box 9000, Halifax, Nova Scotia B3K 6A3, Canada

William M. Whelan

University of Prince Edward Island, Department of Physics, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3, Canada

University of Prince Edward Island, Atlantic Veterinary College, Department of Biomedical Sciences, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3, Canada

J. Biomed. Opt. 18(7), 077005 (Jul 17, 2013). doi:10.1117/1.JBO.18.7.077005
History: Received March 8, 2013; Revised June 18, 2013; Accepted June 20, 2013
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Abstract.  Gold nanoparticles can be used as molecular contrast agents binding specifically to cancer sites and thus delineating tumor regions. Imaging gold nanoparticles deeply embedded in tissues with optical techniques possesses significant challenges due to multiple scattering of optical photons that blur the obtained images. Both diagnostic and therapeutic applications can benefit from a minimally invasive technique that can identify, localize, and quantify the payloads of gold nanoparticles deeply embedded in biological tissues. An optical radiance technique is applied to map localized inclusions of gold nanorods in 650- to 900-nm spectral range in a porcine phantom that mimics prostate geometry. Optical radiance defines a variation in the angular density of photons impinging on a selected point in the tissue from various directions. The inclusions are formed by immersing a capillary filled with gold nanorods in the phantom at increasing distances from the detecting fiber. The technique allows the isolation of the spectroscopic signatures of the inclusions from the background and identification of inclusion locations in the angular domain. Detection of 4×1010 gold nanoparticles or 0.04mgAu/mL (detector–inclusion separation 10 mm, source–detector separation 15 mm) in the porcine tissue is demonstrated. The encouraging results indicate a promising potential of radiance spectroscopy in early prostate cancer diagnostics with gold nanoparticles.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Serge Grabtchak ; Elena Tonkopi and William M. Whelan
"Optical detection of gold nanoparticles in a prostate-shaped porcine phantom", J. Biomed. Opt. 18(7), 077005 (Jul 17, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.7.077005


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