Research Papers: Therapeutic

Two-photon excited quantum dots as energy donors for photosensitizer chlorin e6

[+] Author Affiliations
Artiom Skripka, Jurga Valanciunaite, Gediminas Dauderis, Vilius Poderys, Reda Kubiliute

Institute of Oncology of Vilnius University, Biomedical Physics Laboratory, Baublio 3b, LT-08406 Vilnius, Lithuania

Ricardas Rotomskis

Institute of Oncology of Vilnius University, Biomedical Physics Laboratory, Baublio 3b, LT-08406 Vilnius, Lithuania

Vilnius University, Biophotonics Group of Laser Research Center, Faculty of Physics, Sauletekio 9, Building 3, LT-10222 Vilnius, Lithuania

J. Biomed. Opt. 18(7), 078002 (Jul 17, 2013). doi:10.1117/1.JBO.18.7.078002
History: Received December 31, 2012; Revised June 13, 2013; Accepted June 17, 2013
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Abstract.  The excitation-related problems in photodynamic therapy of cancer might be solved by combining two-photon (TP) irradiation and quantum dots (QDs) as effective energy donors for conventional photosensitizers (PS). Here, it is demonstrated for the first time that QD–chlorin e6 (Ce6) complex formed due to the hydrophobic interaction between Ce6 molecules and lipid coating of QDs can be effectively excited via TP irradiation at 1030 nm, which spectrally coincides with the biological tissue optical window. TP absorption cross-section for free QDs and Ce6 at 1030 nm was 3325 and 13 Goeppert-Mayer, respectively. Upon TP excitation of QDCe6 solution, the fluorescence band of bound Ce6 molecules was observed via energy transfer from excited QDs. Increasing concentration of Ce6 resulted in quenching of the photoluminescence of QDs and an increase in the fluorescence intensity of bound Ce6 molecules. These intensity changes coincided well with those observed upon single-photon excitation of QDCe6 solution when QDs alone are excited. The efficiency of energy transfer in QDCe6 complex upon TP excitation was about 80% (QDCe615). These results indicate that the effective excitation of PS with a low TP absorption cross-section is possible in such type noncovalent complexes via energy transfer from TP excited QDs.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Artiom Skripka ; Jurga Valanciunaite ; Gediminas Dauderis ; Vilius Poderys ; Reda Kubiliute, et al.
"Two-photon excited quantum dots as energy donors for photosensitizer chlorin e6", J. Biomed. Opt. 18(7), 078002 (Jul 17, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.7.078002


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