Special Section on Optical Imaging, Sensing, and Light Interactions in Cells and Tissues

Epileptic seizure-induced structural and functional changes in rat femur and tibia bone tissues: a Fourier transform infrared imaging study

[+] Author Affiliations
Sebnem Garip

Middle East Technical University, Department of Biochemistry, 06531 Ankara, Turkey

Istanbul Kemerburgaz University, Department of Medical Biochemistry, Faculty of Medicine, 34217 Istanbul, Turkey

Deniz Sahin

Kocaeli University, Department of Physiology, Faculty of Medicine, Kocaeli, Turkey

Feride Severcan

Middle East Technical University, Department of Biological Sciences, 06531 Ankara, Turkey

J. Biomed. Opt. 18(11), 111409 (Jul 25, 2013). doi:10.1117/1.JBO.18.11.111409
History: Received April 9, 2013; Revised June 28, 2013; Accepted July 2, 2013
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Abstract.  The disease- and drug-related bone disorders are rapidly increasing in the population. It is previously reported that anti-epileptic drugs (AEDs) may cause osteopenia, osteoporosis, and fractures in epilepsy patients. However, it cannot be determined whether the bone disorders in epileptic patients are due to AED therapy and/or to epilepsy and epileptic seizures. There is no study in the literature which investigates the sole effects of epilepsy and epileptic seizures on bone tissues. The current study provides the first report on determination of the possible effects of epilepsy and epileptic seizures on long bone tissues. Wistar Albino Glaxo/Rijswijk rats, which are accepted as genetic rat models for human absence epilepsy, were compared with the healthy Wistar rats to get information about the sole effects of epilepsy and epileptic seizures on bones. Cortical regions of tibia and femur bones were studied by Fourier transform infrared microspectroscopy (FTIRM). According to FTIRM parameters, variation on bone mineral and matrix composition, including decreased mineral content, decreased collagen cross-links, increased carbonate substitution, and larger crystals in epileptic group compared to the healthy one, show severe effects of epilepsy and seizures on bone tissues for the first time.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Sebnem Garip ; Deniz Sahin and Feride Severcan
"Epileptic seizure-induced structural and functional changes in rat femur and tibia bone tissues: a Fourier transform infrared imaging study", J. Biomed. Opt. 18(11), 111409 (Jul 25, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.11.111409


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