Currently available commercial OCT systems for imaging of in vivo anterior segment are limited by shallow scan depth range, image acquisition speed, and poor ability to penetrate tissues that produce high light scatter (e.g., sclera, limbus). These limitations prevent image capture of a cross section of the entire anterior segment (or KPro) in a single B-scan.15 To overcome these limitations, we report on the development and implementation of a switchable imaging depth range SS-OCT system (3.7 to 11.5 mm in air) with 4.5 μm axial resolution, higher image acquisition speed (100 kHz), and deep tissue penetration. This new system was successfully implemented to acquire images of the full anterior segment in patients with the Boston KPro. A schematic diagram of our 1 μm SS-OCT system is shown in Fig. 2. An external cavity tunable laser, from Axsun Technologies, with a central wavelength of 1060 nm, sweep bandwidth of 110 nm, repetition rate of 100 kHz, 46% duty cycle, and average output power of , was used as the light source. A spectrally balanced Michelson fiber interferometer configuration was used with three fiber couplers (AC Photonics, Santa Clara, California).39 To achieve a complex conjugate resolved SS-OCT system, cavity offset configuration of the laser was used to take advantage of the Axun’s SS “coherence revival.”40 The sample port was attached to a scanning head, which consists of a fiber collimator lens (12.38 mm, focal length, TC12APC-1064, Thorlabs, Inc., Newton, New Jersey), a two-axis galvo mirror (Cambridge Technology, Bedford, Massachusetts), and interchangeable achromatic doublets with two different focal lengths. The reference port of the fiber coupler is attached to a reference unit comprising a collimator lens, an achromatic doublet lens, and a static silver-coated mirror.