Special Section on Advanced Biomedical Imaging and Sensing

Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging

[+] Author Affiliations
Fadi El-Ghussein, Michael A. Mastanduno, Shudong Jiang, Brian W. Pogue, Keith D. Paulsen

Dartmouth College, Thayer School of Engineering, Hanover NH 03755

J. Biomed. Opt. 19(1), 011010 (Aug 26, 2013). doi:10.1117/1.JBO.19.1.011010
History: Received March 26, 2013; Revised June 25, 2013; Accepted July 22, 2013
Text Size: A A A

Abstract.  A new optical parallel detection system of hybrid frequency and continuous-wave domains was developed to improve the data quality and accuracy in recovery of all breast optical properties. This new system was deployed in a previously existing system for magnetic resonance imaging (MRI)-guided spectroscopy, and allows incorporation of additional near-infrared wavelengths beyond 850 nm, with interlaced channels of photomultiplier tubes (PMTs) and silicon photodiodes (PDs). The acquisition time for obtaining frequency-domain data at six wavelengths (660, 735, 785, 808, 826, and 849 nm) and continuous-wave data at three wavelengths (903, 912, and 948 nm) is 12 min. The dynamic ranges of the detected signal are 105 and 106 for PMT and PD detectors, respectively. Compared to the previous detection system, the SNR ratio of frequency-domain detection was improved by nearly 103 through the addition of an RF amplifier and the utilization of programmable gain. The current system is being utilized in a clinical trial imaging suspected breast cancer tumors as detected by contrast MRI scans.

Figures in this Article
© 2014 Society of Photo-Optical Instrumentation Engineers

Citation

Fadi El-Ghussein ; Michael A. Mastanduno ; Shudong Jiang ; Brian W. Pogue and Keith D. Paulsen
"Hybrid photomultiplier tube and photodiode parallel detection array for wideband optical spectroscopy of the breast guided by magnetic resonance imaging", J. Biomed. Opt. 19(1), 011010 (Aug 26, 2013). ; http://dx.doi.org/10.1117/1.JBO.19.1.011010


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement


 

  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.