Special Section on Optical Imaging, Sensing, and Light Interactions in Cells and Tissues

Trimodal detection of early childhood caries using laser light scanning and fluorescence spectroscopy: clinical prototype

[+] Author Affiliations
Liang Zhang

University of Washington, Department of Bioengineering, Seattle, Washington 98195

Amy S. Kim, Joel H. Berg

University of Washington, Department of Pediatric Dentistry, Seattle, Washington 98195

Jeremy S. Ridge, Leonard Y. Nelson, Eric J. Seibel

University of Washington, Department of Mechanical Engineering, Seattle, Washington 98195

J. Biomed. Opt. 18(11), 111412 (Aug 28, 2013). doi:10.1117/1.JBO.18.11.111412
History: Received April 26, 2013; Revised June 13, 2013; Accepted July 12, 2013
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Abstract.  There is currently a need for a safe and effective way to detect and diagnose early stages of childhood caries. A multimodal optical clinical prototype for diagnosing caries demineralization in vivo has been developed. The device can be used to quickly image and screen for any signs of demineralized enamel by obtaining high-resolution and high-contrast surface images using a 405-nm laser as the illumination source, as well as obtaining autofluorescence and bacterial fluorescence images. When a suspicious region of demineralization is located, the device also performs dual laser fluorescence spectroscopy using 405- and 532-nm laser excitation. An autofluorescence ratio of the two excitation lasers is computed and used to quantitatively diagnose enamel health. The device was tested on five patients in vivo as well as on 28 extracted teeth with clinically diagnosed carious lesions. The device was able to provide detailed images that highlighted the lesions identified by the clinicians. The autofluorescence spectroscopic ratios obtained from the extracted teeth successfully quantitatively discriminated between sound and demineralized enamel.

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© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Liang Zhang ; Amy S. Kim ; Jeremy S. Ridge ; Leonard Y. Nelson ; Joel H. Berg, et al.
"Trimodal detection of early childhood caries using laser light scanning and fluorescence spectroscopy: clinical prototype", J. Biomed. Opt. 18(11), 111412 (Aug 28, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.11.111412


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