Laser treatment is suitable for certain types of patients such as those who may have multiple BCCs due to underlying hereditary disorders, excessive sun exposure or long-term immunosuppression, or those who may not tolerate surgical procedures, or those who may have low tolerance for the inflammatory side effects of topical therapies.5–8 Laser ablation, e.g., is effective for treating superficial and nodular BCCs.9–11 The treatment is relatively quick and convenient to perform in a single patient visit, and is minimally invasive, with finely controlled micrometer-level removal of tissue, reduced bleeding, scarring and infection, quicker recovery, and better cosmetic outcome. However, efficacy and reliability tend to be variable because the tissue is vaporized such that none is available for subsequent histopathological examination for residual BCC. Histopathologic examination is necessary and usually performed to confirm complete removal of tumor. (For example, during Mohs surgery, the BCC is removed in stages and the excision at each stage is examined for residual tumor by frozen histopathology. The presence and location of residual tumor guide the excision during the subsequent stage. This process of excision in stages continues until the histopathology indicates complete removal of tumor.) For laser ablation, this limitation may be addressed with high-resolution optical imaging that may detect BCC tumor directly on the patient.