Research Papers: Sensing

Spatiotemporal analysis for indocyanine green-aided imaging of rheumatoid arthritis in hand joints

[+] Author Affiliations
Pouyan Mohajerani, Vasilis Ntziachristos

Technische Universität München and Helmholtz Zentrum München, Institute for Biological and Medical Imaging, Ingolstädter Landstrasse 1, Neuherberg 85764, Germany

Reinhard Meier, Peter B. Noël, Ernst J. Rummeny

Technische Universität München, Department of Radiology, Klinikum Rechts der Isar, Munich 81675, Germany

J. Biomed. Opt. 18(9), 097004 (Sep 17, 2013). doi:10.1117/1.JBO.18.9.097004
History: Received March 29, 2013; Revised August 14, 2013; Accepted August 19, 2013
Text Size: A A A

Abstract.  Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease, with a prevalence of 0.5 to 1% in the general population. Imaging can possibly aid in early diagnosis, crucial to effective personalized therapeutic strategies and treatment follow-up. The intravenous administration of indocyanine green (ICG) has been considered for identifying synovial hyperperfusion as an RA physiological biomarker. However, while the distribution of ICG in the human hand is a time-dependent process, the particular biodistribution dynamic patterns established following intravenous administration have not yet been studied. For this reason, the dynamic relationships of ICG distribution in the human hand in RA patients using a method based on principal component analysis are analyzed. In vivo analyses were corroborated by simulations of clinical scenarios using a finite element method. Observations of spatiotemporal characteristics are contrasted to fluorescence intensity images and magnetic resonance images of the hand joints, employed as the anatomical and diagnostic reference. Processing results for 450 joints from 5 healthy volunteers and 10 patients show that image features obtained from the spatiotemporal analysis offer good congruence with synovitis and reveal better detection performance compared to observations of raw fluorescence intensity images.

Figures in this Article
© 2013 Society of Photo-Optical Instrumentation Engineers

Citation

Pouyan Mohajerani ; Reinhard Meier ; Peter B. Noël ; Ernst J. Rummeny and Vasilis Ntziachristos
"Spatiotemporal analysis for indocyanine green-aided imaging of rheumatoid arthritis in hand joints", J. Biomed. Opt. 18(9), 097004 (Sep 17, 2013). ; http://dx.doi.org/10.1117/1.JBO.18.9.097004


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.